Completed study
Official Study Title
A randomized Clinical Trial for enhanced trained Immune responses through bacillus calmette-guérin VAccination to prevenT infections of the Elderly (ACTIVATE)
Brief Description
ACTIVATE is a randomized clinical trial aiming to investigate if the developing concept of trained immunity i.e. the memory of the innate immune system coming after vaccination exists in humans and may lead to protection from infections.
Details
Status: Completed
Study Type: Interventional (Clinical Trial)
Study phase: IV
Study sites: 1 site in Greece
Actual enrolment: 200 participants
ClinicalTrials.gov Identifier: NCT03296423
EudraCT number: 2017-000596-87
National Organization for Medicines Approval: IS024-17
National Ethics Committee Approval: 27/17
Study Start: September 2017
Study Completion: November 2020
Condition/Disease studied: Infection; Hospitalization; Mortality
Keywords: BCG vaccination
Related publications
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- Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly
Cell 2020 Oct 15;183(2):315-323.e9 - Impact of comorbidities on the performance of interferon-gamma release assay in an elderly Greek population without overt immunodeficiency
International Journal of Antimicrobial Agents 2020 Sep;56(3):106073
- Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly