hiss, Author at HISS

12 May, 2025

Procalcitonin-guided early cessation of antibiotics prevents gut inflammation and preserves gut microbiome: Data from the PROGRESS controlled trial

2025-05-12T15:05:05+03:00By hiss|Categories: Biomarkers, Publications|Tags: microbiome, procalcitonin, Sepsis|

Evdoxia Kyriazopoulou, Emmanouil Stylianakis, Georgia Damoraki, Panagiotis Koufargyris, Ioannis Kollias, Konstantina Katrini, Elina Drakou, Konstantinos Marousis, Andronikos Spyrou, Styliani Symbardi, Nikolaos Alexiou, Zoi Alexiou, Malvina Lada, Garyfallia Poulakou, Georgios Chrysos, George Adamis, Evangelos J. Giamarellos-Bourboulis Int J Antimicrob Agents. 2025 Apr 9:107507 DOI: 10.1016/j.ijantimicag.2025.107507 View article 🡆 FundingHellenic Institute for the Study of Sepsis

9 April, 2025

The EMBRACE trial at the 44th International Symposium of Intensive Care and Emergency Medicine

2025-04-09T09:31:05+03:00By hiss|Categories: Publications, Sepsis and severe infections|Tags: emapalumab, Interferon-gamma, poster, Studies on Sepsis and severe infections|

Ourania Konstantinidou, Elisavet Olntasi, Helena Florou, Souzana Anisoglou, Eleni Antoniadou, George Dimopoulos, Eleni Gkeka, Aikaterini Ioakeimidou, Vassileios Karamouzos, Efmorphia Kondili, Zafeiria Mastora, Eleni Mouloudi, Pavlos Myrianthefs, Maria Ntaganou, Elissavet Paramythiotou, Vassilis Papaioannou, Maria Patrani, Nikoletta Rovina, Glykeria Vlachogianni, Armin J. Reininger, Evangelos J. Giamarellos-Bourboulis 44th International Symposium of Intensive Care and Emergency

12 March, 2025

EMBRACE

2025-04-09T09:25:03+03:00By hiss|Categories: Interventional, Ongoing, Sepsis and severe infections, Studies|Tags: emapalumab, IFNγ, infections, Sepsis|

Ongoing study Official Study Title EMapalumaB treatment foR Anticipated Clinical benefit in sepsis driven by the Interferon-Gamma Endotype (The EMBRACE trial) Brief Description In a recent analysis of 5,503 patients with sepsis meeting the Sepsis-3 definitions and coming from Germany, Greece and Italy randomized into one discovery set and one validation set, it was

26 February, 2025

Recent advances of precision immunotherapy in sepsis

2025-03-10T10:51:58+03:00By hiss|Categories: Publications|Tags: Anakinra, Interferon-gamma, Sepsis|

Antonios Arapis, Dimitrios Panagiotopoulos, Evangelos J. Giamarellos-Bourboulis Burns & Trauma, 2025, 13, tkaf001 DOI: 10.1093/burnst/tkaf001Download pdf 🡇 Keywords: Precision immunotherapy; Sepsis; Anakinra; Nangibotide; Nivolumab; Interferon-gamma; Growth factors; Adrecizumab

10 January, 2025

Clarithromycin for improved clinical outcomes in community-acquired pneumonia: A subgroup analysis of the ACCESS trial

2025-01-10T13:53:31+03:00By hiss|Categories: Publications, Therapeutics|Tags: clarithromycin, pneumonia|

Karolina Akinosoglou, Konstantinos Leventogiannis, Elisavet Tasouli, Nikolaos Kakavoulis, Georgios Niotis, Sarantia Doulou, Lamprini Skorda, Konstantina Iliopoulou, Anna Papailiou, Paraskevi Katsaounou, Vassiliki Rapti, George Chrysos, Theodoros Seferlis, Styliani Gerakari, Konstantina Dakou, Ilias C. Papanikolaou, Haralampos Milionis, Samantha Kewitz, Sara Georgiadou, Theano Kontopoulou, Vasiliki Tzavara, Antonio Torres, Michael S. Niederman, Evangelos J. Giamarellos-Bourboulis Int

10 January, 2025

Anakinra Efficacy in COVID-19 Pneumonia Guided by Soluble Urokinase Plasminogen Activator Receptor: Association With the Inflammatory Burden of the Host

2025-01-10T13:53:22+03:00By hiss|Categories: Biomarkers, Publications|Tags: Anakinra, COVID-19, mortality, suPAR|

Evdoxia Kyriazopoulou, Karolina Akinosoglou, Eleni Florou, Elli Kouriannidi, Artemis Bogosian, Olga Tsachouridou, Konstantinos N. Syrigos, Nikolaos Gatselis, Haralampos Milionis, Ilias C. Papanikolaou, Styliani Sympardi, Maria Dafni, Antonia Alevizou, Alexia-Vasiliki Amvrazi, Errika Alexandrou, Kyprianos Archontoulis, Katerina Argyraki, Zoi Alexiou, Yakinthi Georgiou, Dimitra Gkogka, Foteini Kyrailidi, Vassiliki Kalyva, Triantafilli Nikolopoulou, Sofia Ioannou, Petros Bakakos, Georgia Karathanassiou,

27 December, 2024

POINT study

2025-01-09T10:44:40+03:00By hiss|Categories: Non-Interventional, Ongoing, Sepsis and severe infections, Studies|Tags: complications, COVID-19, post-acute, prevention|

Personalised care for post-COVID-19 health Connect to the official POINT website Ongoing study Official Study Title A non-interventional, Prospective, cross-sectional study Of the INcidence of pulmonary, cardiovascular and renal system non-communicable complications associated with the post-acute phase of the infecTion by SARS-CoV-2 Brief Description POINT is an innovative research project funded

29 November, 2024

HOMI-LUNG CAP

2025-01-09T10:15:28+03:00By hiss|Categories: Non-Interventional, Ongoing, Sepsis and severe infections, Studies|Tags: cardiovascular, COVID-19, pneumonia|

A STRONG CONSORTIUM TO FILL THE GAP Pneumonia is a heart matter too (and viceversa) Connect to the official HOMI-LUNG CAP website Ongoing study Official Study Title A non-interventional, prospective, cross-sectional study of cardiovascular disease progression in survivors of community acquired pneumonia and lung infection by SARS-CoV-2 Brief Description HOMI-LUNG is

25 October, 2024

Interferon-gamma driven elevation of CXCL9: a new sepsis endotype independently associated with mortality

2024-10-25T09:53:56+03:00By hiss|Categories: Biomarkers, Publications|Tags: Interferon-gamma, mortality, Sepsis|

Evangelos J. Giamarellos-Bourboulis, Massimo Antonelli, Frank Bloos, Ioanna Kotsamidi, Christos Psarrakis, Konstantina Dakou, Daniel Thomas-Rüddel, Luca Montini, Josef Briegel, Georgia Damoraki, Panagiotis Koufargyris, Souzana Anisoglou, Eleni Antoniadou, Glykeria Vlachogianni, Christos Tsiantas, Matteo Masullo, Aikaterini Ioakeimidou, Eumorfia Kondili, Maria Ntaganou, Eleni Gkeka, Vassileios Papaioannou, Effie Polyzogopoulou, Armin J Reininger, Gennaro De Pascale, Michael Kiehntopf, Eleni

25 September, 2024

HEPARIN-BINDING PROTEIN LEVELS PREDICT UNFAVORABLE OUTCOME IN COVID-19 PNEUMONIA: A POST HOC ANALYSIS OF THE SAVE TRIAL

2024-10-18T12:27:27+03:00By hiss|Categories: Biomarkers, Multicenter studies in Greece, Publications|Tags: COVID-19, heparin-binding protein, mortality, pneumonia|

Evdoxia Kyriazopoulou , George N Dalekos, Symeon Metallidis, Garyphalia Poulakou, Ilias C Papanikolaou, Vasiliki Tzavara, Katerina Argyraki, Zoi Alexiou, Periklis Panagopoulos, Michael Samarkos, George Chrysos, Aikaterini Tseliou, Haralampos Milionis, Styliani Sympardi, Anil Vasishta, Evangelos J. Giamarellos-Bourboulis Shock 2024 Mar 1;61(3):395-399. DOI: 10.1097/SHK.0000000000002315View article 🡆 Funding This study was supported in part

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