hiss – HISS

28 October, 2023

Impact of Single Nucleotide Polymorphisms of the Promoter of the TNF Gene on Adalimumab Treatment Responses in Hidradenitis Suppurativa

2023-10-28T20:24:17+03:00By hiss|Categories: Publications, Therapeutics|Tags: Adalimumab, Hidradenitis suppurativa|

Maria Argyropoulou, Anastasia Trigoni, Jessica Kaffenberger, Dimitra Stergianou, Georgia Damoraki, Elissavet Mingiani, Styliani Micha, Andrew Krispinsky, Parthena Meltzanidou, Theodora Kanni, Elizabeth Lazaridou, Evangelos J. Giamarellos-Bourboulis Dermatology (2023) 239 (5): 746–752 DOI: 10.1159/000531558Download pdf 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: Adalimumab, Hidradenitis

12 September, 2023

A randomized clinical trial of bermekimab treatment for clinical improvement of systemic sclerosis

2023-10-08T16:00:21+03:00By hiss|Categories: Publications, Therapeutics|Tags: bermekimab, clinical trial, systemic sclerosis|

Nicky Solomonidi, Panayiotis G. Vlachoyiannopoulos, Maria Pappa, Georgia Liantinioti, Sofia Ktena, Evangelos Theotikos, Antonia Elezoglou, Mihai G. Netea, and Evangelos J. Giamarellos-Bourboulis iScience 2023 Aug 19;26(9):107670 DOI: 10.1016/j.isci.2023.107670Download pdf 🡇 Funding The study was supported in part by the Hellenic Institute for the Study of Sepsis and in part by Janssen.

7 September, 2023

Immune responses of patients on maintenance hemodialysis after infection by SARS-CoV-2: a prospective observational cohort study

2023-09-07T17:24:36+03:00By hiss|Categories: Publications|Tags: COVID-19, cytokines|

Dimitra Bacharaki, Minas Karagiannis, Panagiotis Giannakopoulos, Evangelos Papachristou, Dimitrios Divanis, Aggeliki Sardeli, Dimitra Petrou, Petros Nikolopoulos, Adamantia Bratsiakou, Vassiliki Zoi, Nikitas Piliouras, Georgia Damoraki, Vassilios Liakopoulos, Dimitrios Goumenos and Evangelos J. Giamarellos-Bourboulis BMC Infectious Diseases (2023) 23:581 DOI: 10.1186/s12879-023-08569-2Download pdf 🡇 Funding The study was funded by the Hellenic Institute for

3 August, 2023

Sepsis, a call for inclusion in the work plan of the European Center for Disease Prevention and Control

2023-09-21T14:44:33+03:00By hiss|Categories: Publications|Tags: letter, Sepsis|

Evangelos J. Giamarellos-Bourboulis on behalf of the European Sepsis Alliance (ESA), Annelies S. Zinkernagel on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Edoardo De Robertis on behalf of the European Society of Anesthesiology and Intensive Care (ESAIC), Élie Azoulay on behalf of the European Society for Intensive Care Medicine

7 July, 2023

Analysis of inflammatory protein profiles in the circulation of COVID-19 patients identifies patients with severe disease phenotypes

2023-07-07T09:39:43+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19, phenotypes|

Nick Keur, Maria Saridaki, Isis Ricano-Ponce, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar Respiratory Medicine 2023 Jun 25; 217:107331 DOI: 10.1016/j.rmed.2023.107331Download pdf 🡇 Funding This work was funded by the ZonMw (10430012010002) to VK. The SAVE study was funded by the Hellenic Institute for the Study of Sepsis, Swedish Orphan

9 March, 2023

Presepsin as a diagnostic and prognostic biomarker of severe bacterial infections and COVID‑19

2023-03-09T12:07:30+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19|

Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Georgios Tavoulareas, Efstratios Mainas, Konstantinos Toutouzas, Christos Mathas, Athanassios Prekates, Vissaria Sakka, Periklis Panagopoulos, Konstantinos Syrigos & Evangelos J. Giamarellos-Bourboulis Scientific Reports 13, Article number: 3814 (2023) DOI: 10.1038/s41598-023-30807-5Download pdf 🡇 Funding The study was funded in part by the FrameWork 7 project HemoSpec (Grant 611682) and in part

15 February, 2023

MODIFY

2023-02-15T20:41:14+03:00By hiss|Categories: Ongoing, Sepsis and severe infections, Studies|Tags: procalcitonin, Sepsis|

Ongoing study Official Study Title A RANDOMIZED PROSPECTIVE CLINICAL TRIAL TO ASSESS PROCALCITONIN-GUIDANCE AND MOLECULAR-GUIDED DIAGNOSIS AS MAINSTAY FOR THERAPY OF SEVERE INFECTIONS (The MODIFY trial) Brief Description The aim of the study is to demonstrate if using a combined strategy of rapid molecular diagnosis with BioFire® FilmArray® Blood Culture Identification 2 Panel and

10 February, 2023

Case report: The devil was hidden in the mastocytes – an unusually fulminant case of indolent systemic mastocytosis in a 45-year-old patient, missed for almost 20 years

2023-02-16T12:24:58+03:00By hiss|Categories: Epidemiology, Publications|

Aristeidis E. Boukouris, Ioannis Michelakis, Dionysios Metaxas, Gianna Karapati, George Kanellis, Athina Lioni, Vasiliki Tzavara Frontiers Immunology, 14:1134587 DOI: 10.1111/cea.12318Download pdf 🡇 Funding This study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: Case report

1 February, 2023

HDM-FUN-Candidemia

2023-02-16T11:12:54+03:00By hiss|Categories: Interventional, Ongoing, Sepsis and severe infections, Studies|Tags: candidemia|

Ongoing study Official Study Title Safety and Efficacy of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Candidemia: The HDM-FUN-Candidemia trial Brief Description Invasive fungal infections are an important cause of morbidity and mortality and lead to numerous hospital and ICU admissions. Candidemia is associated with a suppressed immune status

10 January, 2023

SAVE-LONG

2023-05-22T14:50:00+03:00By hiss|Categories: Non-Interventional, Ongoing, Sepsis and severe infections, Studies|Tags: COVID-19|

Ongoing study Official Study Title Symptom-guided Anakinra treatment for the Validation of immunE dysfunction persisting for LONG after hospital discharge for COVID-19 (SAVE-LONG) Brief Description SAVE-LONG is a call to the development of diagnostic tools and therapeutic modalities for patients with Long-COVID Syndrome. Details Status: ongoing Study Type: Non-interventional Study phase: II &

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