Completed study
Official Study Title
A prospective, open label, randomized controlled clinical trial, with pharmacokinetic-pharmacodynamic validation, to compare antimicrobial treatment with oral minocycline plus rifampicin to treatment with oral linezolid for complicated skin and skin structure infections (cSSSI) caused by methicillin-resistant Staphylococcus aureus (MRSA)
Brief Description
The AIDA consortium is a European Consortium funded by the Seventh Framework Program of the EU to run three randomized clinical trials in different infectious diseases aiming to prove that old and cheap antimicrobials remain equally active to newer and more expensive antimicrobials. The Work Package 2 of the AIDA was run by the HISS through collaboration with Micron Research Ltd.
Details
Status: Completed
Study Type: Interventional (Clinical Trial)
Study phase: IV
Study sites: 17 sites in Greece
Actual enrolment: 121 participants
EudraCT number: 2014-001276-56
National Organization for Medicines Approval: IS083-14
National Ethics Committee Approval: 87/14
Study Start: November 2014
Study Completion: December 2016
Condition/Disease studied: Complicated skin and skin structure infections (cSSSI)
Keywords: cSSSI
Related publications
- Microbiology of acute bacterial skin and skin-structure infections in Greece: A proposed clinical prediction score for the causative pathogen
International Journal of Antimicrobial Agents 2019 Dec;54(6):750-756 - Oral minocycline plus rifampicin versus oral linezolid for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: The AIDA open label, randomized, controlled Phase 4 trial
eClinicalMedicine 56, 101790, February 01, 2023