Evdoxia Kyriazopoulou, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Georgios Adamis, Konstantinos Tsiakos, Archontoula Fragkou, Aggeliki Rapti, Christina Damoulari, Massimo Fantoni, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Maria Tsilika, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Evangelos Kostis, Lorenzo Dagna, Panagiotis Koufargyris, Katerina Dimakou, Spyridon Savvanis, Glykeria Tzatzagou, Maria Chini, Giulio Cavalli, Matteo Bassetti, Konstantina Katrini, Vasileios Kotsis, George Tsoukalas, Carlo Selmi, Ioannis Bliziotis, Michael Samarkos, Michael Doumas, Sofia Ktena, Aikaterini Masgala, Ilias Papanikolaou, Maria Kosmidou, Dimitra-Melia Myrodia, Aikaterini Argyraki, Chiara Simona Cardellino, Katerina Koliakou, Eleni-Ioanna Katsigianni, Vassiliki Rapti, Efthymia Giannitsioti, Antonella Cingolani, Styliani Micha, Karolina Akinosoglou, Orestis Liatsis-Douvitsas, Styliani Symbardi, Nikolaos Gatselis, Maria Mouktaroudi, Giuseppe Ippolito, Eleni Florou, Antigone Kotsaki, Mihai G Netea, Jesper Eugen-Olsen, Miltiades Kyprianou, Periklis Panagopoulos, George N Dalekos, Evangelos J. Giamarellos-Bourboulis

Early treatment of COVID-19 with anakinra guided by solubl urokinase plasminogen receptor plasma levels

Nature Medicine 2021 Oct;27(10):1752-1760
DOI: 10.1038/s41591-021-01499-zDownload pdf 🡇

Funding

The authors wish to express their gratitude to the members of the Data Monitoring and Safety Committee and to M. Niederman, J. W. M. van der Meer and K. Reinhart for their valuable contributions and for their critical review of the submitted manuscript. This trial was sponsored by the Hellenic Institute for the Study of Sepsis (HISS) and funded, in part, by HISS and, in part, by Swedish Orphan Biovitrum (Sobi). HISS was responsible for the conceptualization and design of the study, data collection, analysis, decision to publish and preparation of the manuscript. Sobi had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

Keywords:  COVID-19; Anakinra
Related Studies: SAVE-MORE