Therapeutics

27 December, 2022

Efficacy and safety of early soluble urokinase plasminogen receptor plasma-guided anakinra treatment of COVID-19 pneumonia: A subgroup analysis of the SAVE-MORE randomised trial

2023-02-16T12:27:12+03:00By hiss|Categories: Publications, Therapeutics|Tags: Anakinra, clinical trial, COVID-19, suPAR|

Karolina Akinosoglou, Antigone Kotsaki, Ioanna-Maria Gounaridi, Eirini Christaki, Simeon Metallidis, Georgios Adamis, Archontoula Fragkou, Massimo Fantoni, Aggeliki Rapti, Ioannis Kalomenidis, Georgios Chrysos, Gloria Boni, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Asimina Safarika, Sofia Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios

27 December, 2022

Oral minocycline plus rifampicin versus oral linezolid for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: The AIDA open label, randomized, controlled Phase 4 trial

2023-02-16T12:28:17+03:00By hiss|Categories: Publications, Therapeutics|Tags: clinical trial, skin infections|

Antigone Kotsaki, Nikolaos Tziolos, Theano Kontopoulou, Ioannis M. Koutelidakis, Styliani Symbardi, Vaughan Reed, Miriam O’Hare, Zoi Alexiou, Helen Sambatakou, Konstantinos Toutouzas, Karolina Akinosoglou, Malvina Lada, Evangelos J. Giamarellos-Bourboulis, and Alasdair MacGowan eClinicalMedicine Volume 56, 101790, February 01, 2023 DOI: 10.1016/j.eclinm.2022.101790Download pdf 🡇 Funding The EU Seventh Research Framework Programme. Keywords: Minocycline;

21 December, 2022

ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol

2023-02-16T12:30:26+03:00By hiss|Categories: Publications, Therapeutics|Tags: clinical trial, Sepsis, SOFA|

Antigone Kotsaki, Peter Pickkers , Michael Bauer, Thierry Calandra, Mihaela Lupse, W Joost Wiersinga, Sylvain Meylan , Frank Bloos, Tom van der Poll, Marleen A Slim , Niels van Mourik, Marcella C A Müller, Lonneke van Vught,8 Alexander P J Vlaar, Aline de Nooijer, Lieke Bakkerus, Sebastian Weis, Nikolaos Antonakos, Mihai G Netea, Evangelos

5 July, 2022

ACTIVATE-2: A Double-Blind Randomized Trial of BCG Vaccination Against COVID-19 in Individuals at Risk

2023-02-16T12:35:33+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: BCG, clinical trial, COVID-19, vaccination|

Maria Tsilika, Esther Taks, Konstantinos Dolianitis, Antigone Kotsaki, Konstantinos Leventogiannis, Christina Damoulari, Maria Kostoula, Maria Paneta, Georgios Adamis, Ilias Papanikolaou, Kimon Stamatelopoulos, Amalia Bolanou, Konstantinos Katsaros, Christina Delavinia, Ioannis Perdios, Aggeliki Pandi, Konstantinos Tsiakos, Nektarios Proios, Emmanouela Kalogianni, Ioannis Delis, Efstathios Skliros, Karolina Akinosoglou, Aggeliki Perdikouli, Garyfallia Poulakou, Haralampos Milionis, Eva Athanassopoulou, Eleftheria Kalpaki,

1 May, 2022

ESCAPE: An Open-Label Trial of Personalized Immunotherapy in Critically ill COVID-19 Patients

2023-02-16T12:38:00+03:00By hiss|Categories: Publications, Therapeutics|Tags: clinical trial, COVID-19, Tocilizumab|

Eleni Karakike, George N Dalekos, Ioannis Koutsodimitropoulos, Maria Saridaki, Chryssa Pourzitaki, Georgios Papathanakos, Antigone Kotsaki, Stamatios Chalvatzis, Vasiliki Dimakopoulou, Nikolaos Vechlidis, Elisabeth Paramythiotou, Christina Avgoustou, Aikaterini Ioakeimidou, Elli Kouriannidi, Apostolos Komnos, Evangelia Neou, Nikoletta Rovina, Eleni Stefanatou, Haralampos Milionis, George Nikolaidis, Antonia Koutsoukou, Georgia Damoraki, George Dimopoulos, Vassileios Zoumpos, Jesper Eugen-Olsen, Karolina Akinosoglou, Nikolaos

1 October, 2021

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

2023-02-16T13:23:01+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: Anakinra, clinical trial, COVID-19|

Evdoxia Kyriazopoulou, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Georgios Adamis, Konstantinos Tsiakos, Archontoula Fragkou, Aggeliki Rapti, Christina Damoulari, Massimo Fantoni, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Maria Tsilika, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Evangelos Kostis, Lorenzo Dagna, Panagiotis Koufargyris, Katerina Dimakou, Spyridon Savvanis, Glykeria

1 September, 2021

The Role of Macrolides for the Management of Community-Acquired Pneumonia and Pneumonia by the Novel Coronavirus SARS-CoV-2 (COVID-19): A Position Paper by Four Medical Societies from Greece

2023-02-16T13:23:58+03:00By hiss|Categories: Publications, Therapeutics|Tags: clarithromycin, COVID-19, pneumonia|

Evangelos J. Giamarellos-Bourboulis, George L Daikos, Panagiotis Gargalianos, Charalambos Gogos, Marios Lazanas, Periklis Panagopoulos, Garyphallia Poulakou, Helen Sambatakou, Michael Samarkos Infectious Diseases and Therapy 2021 Sep;10(3):1081-1095 DOI: 10.1007/s40121-021-00471-1Download pdf 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis. No Rapid Service Fee was received by

8 March, 2021

An open label trial of anakinra to prevent respiratory failure in COVID-19

2023-02-16T13:28:10+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: Anakinra, COVID-19, suPAR|

Evdoxia Kyriazopoulou, Periklis Panagopoulos, Symeon Metallidis, George N Dalekos, Garyphallia Poulakou, Nikolaos Gatselis, Eleni Karakike, Maria Saridaki, Georgia Loli, Aggelos Stefos, Danai Prasianaki, Sarah Georgiadou, Olga Tsachouridou, Vasileios Petrakis, Konstantinos Tsiakos, Maria Kosmidou, Vassiliki Lygoura, Maria Dareioti, Haralampos Milionis, Ilias C Papanikolaou, Karolina Akinosoglou, Dimitra-Melia Myrodia, Areti Gravvani, Aliki Stamou, Theologia Gkavogianni, Konstantina Katrini,

15 January, 2021

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial

2023-01-15T23:40:13+03:00By hiss|Categories: Publications, Therapeutics|Tags: clinical trial, procalcitonin, Sepsis|

Evdoxia Kyriazopoulou, Lydia Liaskou-Antoniou, George Adamis, Antonia Panagaki, Nikolaos Melachroinopoulos, Elina Drakou, Konstantinos Marousis, Georgios Chrysos, Andronikos Spyrou, Nikolaos Alexiou, Styliani Symbardi, Zoi Alexiou, Styliani Lagou, Virginia Kolonia, Theologia Gkavogianni, Miltiades Kyprianou, Ioannis Anagnostopoulos, Garyfallia Poulakou, Malvina Lada, Anna Makina, Efrosyni Roulia, Marina Koupetori, Vasileios Apostolopoulos, Dimitra Petrou, Thomas Nitsotolis, Anastasia Antoniadou, Evangelos J.

1 January, 2020

Survival benefit associated with clarithromycin in severe community-acquired pneumonia: A matched comparator study

2023-02-16T14:31:00+03:00By hiss|Categories: Publications, Therapeutics|Tags: azithromycin, clarithromycin, pneumonia|

Evdoxia Kyriazopoulou, Dimitrios Sinapidis, Stamatios Halvatzis, Dimitrios Velissaris, Nikolaos Alexiou, Vasilios Kosmas, Maria-Evangelia Adami, Miltiades Kyprianou, Aikaterini Kyprianou, Aggelos Stefos, Malvina Lada, Pantelis Koutoukas, Maria Pavlaki, Anna Kyriakoudi, Anna Makina, Charalambos Gogos, Michael S Niederman, Evangelos J. Giamarellos-Bourboulis International Journal of Antimicrobial Agents 2020 Jan;55(1):105836 DOI: 10.1016/j.ijantimicag.2019.10.017View article 🡇 Funding The works were