Therapeutics

4 January, 2024

Clarithromycin for early anti-inflammatory responses in community-acquired pneumonia in Greece (ACCESS): a randomised, double-blind, placebo-controlled trial

2024-04-01T11:51:43+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: clarithromycin, clinical trial, pneumonia|

Evangelos J. Giamarellos-Bourboulis, Athanasios Siampanos, Amalia Bolanou, Sarantia Doulou, Nikolaos Kakavoulis, Konstantinos Tsiakos, Sokratis Katopodis, Georgios Schinas, Lamprini Skorda, Zoi Alexiou, Konstantinos Armenis, Paraskevi Katsaounou, George Chrysos, Aikaterini Masgala, Garyphalia Poulakou, Nikolaos Antonakos, Asimina Safarika, Miltiades Kyprianou, Konstantina Dakou, Styliani Gerakari, Ilias C Papanikolaou, Prof Haralampos Milionis, Prof Markos Marangos, Prof George N Dalekos,

28 October, 2023

Impact of Single Nucleotide Polymorphisms of the Promoter of the TNF Gene on Adalimumab Treatment Responses in Hidradenitis Suppurativa

2023-10-28T20:24:17+03:00By hiss|Categories: Publications, Therapeutics|Tags: Adalimumab, Hidradenitis suppurativa|

Maria Argyropoulou, Anastasia Trigoni, Jessica Kaffenberger, Dimitra Stergianou, Georgia Damoraki, Elissavet Mingiani, Styliani Micha, Andrew Krispinsky, Parthena Meltzanidou, Theodora Kanni, Elizabeth Lazaridou, Evangelos J. Giamarellos-Bourboulis Dermatology (2023) 239 (5): 746–752 DOI: 10.1159/000531558Download pdf 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: Adalimumab, Hidradenitis

12 September, 2023

A randomized clinical trial of bermekimab treatment for clinical improvement of systemic sclerosis

2023-10-08T16:00:21+03:00By hiss|Categories: Publications, Therapeutics|Tags: bermekimab, clinical trial, systemic sclerosis|

Nicky Solomonidi, Panayiotis G. Vlachoyiannopoulos, Maria Pappa, Georgia Liantinioti, Sofia Ktena, Evangelos Theotikos, Antonia Elezoglou, Mihai G. Netea, and Evangelos J. Giamarellos-Bourboulis iScience 2023 Aug 19;26(9):107670 DOI: 10.1016/j.isci.2023.107670Download pdf 🡇 Funding The study was supported in part by the Hellenic Institute for the Study of Sepsis and in part by Janssen.

27 December, 2022

Efficacy and safety of early soluble urokinase plasminogen receptor plasma-guided anakinra treatment of COVID-19 pneumonia: A subgroup analysis of the SAVE-MORE randomised trial

2024-04-03T12:43:50+03:00By hiss|Categories: Publications, Therapeutics|Tags: Anakinra, clinical trial, COVID-19, suPAR|

Karolina Akinosoglou, Antigone Kotsaki, Ioanna-Maria Gounaridi, Eirini Christaki, Simeon Metallidis, Georgios Adamis, Archontoula Fragkou, Massimo Fantoni, Aggeliki Rapti, Ioannis Kalomenidis, Georgios Chrysos, Gloria Boni, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Asimina Safarika, Sofia Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios

27 December, 2022

Oral minocycline plus rifampicin versus oral linezolid for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: The AIDA open label, randomized, controlled Phase 4 trial

2024-04-03T12:38:22+03:00By hiss|Categories: Publications, Therapeutics|Tags: clinical trial, skin infections|

Antigone Kotsaki, Nikolaos Tziolos, Theano Kontopoulou, Ioannis M. Koutelidakis, Styliani Symbardi, Vaughan Reed, Miriam O’Hare, Zoi Alexiou, Helen Sambatakou, Konstantinos Toutouzas, Karolina Akinosoglou, Malvina Lada, Evangelos J. Giamarellos-Bourboulis, and Alasdair MacGowan eClinicalMedicine Volume 56, 101790, February 01, 2023 DOI: 10.1016/j.eclinm.2022.101790Download pdf 🡇 Funding The EU Seventh Research Framework Programme. Keywords: Minocycline; Rifampicin;

21 December, 2022

ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol

2024-04-02T18:40:49+03:00By hiss|Categories: Publications, Therapeutics|Tags: clinical trial, Sepsis, SOFA|

Antigone Kotsaki, Peter Pickkers , Michael Bauer, Thierry Calandra, Mihaela Lupse, W Joost Wiersinga, Sylvain Meylan , Frank Bloos, Tom van der Poll, Marleen A Slim , Niels van Mourik, Marcella C A Müller, Lonneke van Vught,8 Alexander P J Vlaar, Aline de Nooijer, Lieke Bakkerus, Sebastian Weis, Nikolaos Antonakos, Mihai G Netea, Evangelos

5 July, 2022

ACTIVATE-2: A Double-Blind Randomized Trial of BCG Vaccination Against COVID-19 in Individuals at Risk

2024-04-02T18:24:39+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: BCG, clinical trial, COVID-19, vaccination|

Maria Tsilika, Esther Taks, Konstantinos Dolianitis, Antigone Kotsaki, Konstantinos Leventogiannis, Christina Damoulari, Maria Kostoula, Maria Paneta, Georgios Adamis, Ilias Papanikolaou, Kimon Stamatelopoulos, Amalia Bolanou, Konstantinos Katsaros, Christina Delavinia, Ioannis Perdios, Aggeliki Pandi, Konstantinos Tsiakos, Nektarios Proios, Emmanouela Kalogianni, Ioannis Delis, Efstathios Skliros, Karolina Akinosoglou, Aggeliki Perdikouli, Garyfallia Poulakou, Haralampos Milionis, Eva Athanassopoulou, Eleftheria Kalpaki,

1 May, 2022

ESCAPE: An Open-Label Trial of Personalized Immunotherapy in Critically ill COVID-19 Patients

2024-04-02T18:18:52+03:00By hiss|Categories: Publications, Therapeutics|Tags: clinical trial, COVID-19, Tocilizumab|

Eleni Karakike, George N Dalekos, Ioannis Koutsodimitropoulos, Maria Saridaki, Chryssa Pourzitaki, Georgios Papathanakos, Antigone Kotsaki, Stamatios Chalvatzis, Vasiliki Dimakopoulou, Nikolaos Vechlidis, Elisabeth Paramythiotou, Christina Avgoustou, Aikaterini Ioakeimidou, Elli Kouriannidi, Apostolos Komnos, Evangelia Neou, Nikoletta Rovina, Eleni Stefanatou, Haralampos Milionis, George Nikolaidis, Antonia Koutsoukou, Georgia Damoraki, George Dimopoulos, Vassileios Zoumpos, Jesper Eugen-Olsen, Karolina Akinosoglou, Nikolaos

1 October, 2021

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

2024-04-02T18:13:24+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: Anakinra, clinical trial, COVID-19|

Evdoxia Kyriazopoulou, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Georgios Adamis, Konstantinos Tsiakos, Archontoula Fragkou, Aggeliki Rapti, Christina Damoulari, Massimo Fantoni, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Maria Tsilika, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Evangelos Kostis, Lorenzo Dagna, Panagiotis Koufargyris, Katerina Dimakou, Spyridon Savvanis, Glykeria

1 September, 2021

The Role of Macrolides for the Management of Community-Acquired Pneumonia and Pneumonia by the Novel Coronavirus SARS-CoV-2 (COVID-19): A Position Paper by Four Medical Societies from Greece

2024-04-02T18:01:32+03:00By hiss|Categories: Publications, Therapeutics|Tags: clarithromycin, COVID-19, pneumonia|

Evangelos J. Giamarellos-Bourboulis, George L Daikos, Panagiotis Gargalianos, Charalambos Gogos, Marios Lazanas, Periklis Panagopoulos, Garyphallia Poulakou, Helen Sambatakou, Michael Samarkos Infectious Diseases and Therapy 2021 Sep;10(3):1081-1095 DOI: 10.1007/s40121-021-00471-1Download pdf 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis. No Rapid Service Fee was received by the