Publications

14 March, 2024

Transitions of blood immune endotypes and improved outcome by anakinra in COVID-19 pneumonia: an analysis of the SAVE-MORE randomized controlled trial

2024-03-14T14:03:07+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Anakinra, clinical trial, COVID-19, Sepsis|

Evdoxia Kyriazopoulou, Yehudit Hasin‐Brumshtein, Uros Midic, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Myrto Astriti, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vasiliki Tzavara, Sofa Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios

7 February, 2024

qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in the emergency department: a randomized controlled trial

2024-02-07T15:45:40+03:00By hiss|Categories: Biomarkers, Publications|Tags: meropenem, qSOFA, Sepsis, suPAR|

Maria Evangelia Adami, Antigone Kotsaki, Nikolaos Antonakos, Efthymia Giannitsioti, Stamatios Chalvatzis, Maria Saridaki, Christina Avgoustou, Karolina Akinosoglou, Konstantina Dakou, Georgia Damoraki, Konstantina Katrini, Panagiotis Koufargyris, Vasileios Lekakis, Antonia Panagaki, Asimina Safarika, Jesper Eugen‐Olsen and Evangelos J. Giamarellos-Bourboulis Critical Care volume 28, Article number: 42 (2024) DOI: 10.1186/s13054-024-04825-2Download pdf 🡇 Funding The

2 February, 2024

Developing a Tool for Differentiation Between Bacterial and Viral Respiratory Infections Using Myxovirus Resistance Protein A and C-Reactive Protein

2024-02-02T13:03:15+03:00By hiss|Categories: Biomarkers, Publications|Tags: CRP, diagnosis, infection|

Konstantina Iliopoulou, Panagiotis Koufargyris, Sarantia Doulou, Elisavet Tasouli, Sokratis Katopodis, Stavroula-Porphyria Chachali, Georgios Schinas, Charalampos Karachalios, Myrto Astriti, Paraskevi Katsaounou, George Chrysos, Theodoros Seferlis, Effrosyni Dimopoulou, Myrto Kollia, Garyphalia Poulakou, Styliani Gerakari, Ilias C. Papanikolaou, Haralampos Milionis, George N. Dalekos, Vasiliki Tzavara, Theano Kontopoulou, Evangelos J. Giamarellos-Bourboulis Infect Dis Ther. 2024 Jan;13(1):105-119 DOI: 10.1007/s40121-023-00901-2Download

5 January, 2024

Association of Vitamin D with Severity and Outcome of COVID-19: Clinical and Experimental Evidence

2024-01-05T14:33:18+03:00By hiss|Categories: Biomarkers, Publications|Tags: ARDS, COVID-19|

Georgios Renieris, Spyros Foutadakis, Theano Andriopoulou, Victoria-Marina Spanou, Dionyssia-Eirini Droggiti, Dionysios Kafousopoulos , Theologia Gkavogianni, Georgia Damoraki, Giannis Vatsellas, Evangelos J. Giamarellos-Bourboulis J Innate Immun (2023) 16 (1): 1–11DOI: 10.1159/000535302Download pdf 🡇 FundingThe study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: Vitamin D; Tumor necrosis factor; Interleukin-6; Interferon gamma;

4 January, 2024

Clarithromycin for early anti-inflammatory responses in community-acquired pneumonia in Greece (ACCESS): a randomised, double-blind, placebo-controlled trial

2024-04-01T11:51:43+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: clarithromycin, clinical trial, pneumonia|

Evangelos J. Giamarellos-Bourboulis, Athanasios Siampanos, Amalia Bolanou, Sarantia Doulou, Nikolaos Kakavoulis, Konstantinos Tsiakos, Sokratis Katopodis, Georgios Schinas, Lamprini Skorda, Zoi Alexiou, Konstantinos Armenis, Paraskevi Katsaounou, George Chrysos, Aikaterini Masgala, Garyphalia Poulakou, Nikolaos Antonakos, Asimina Safarika, Miltiades Kyprianou, Konstantina Dakou, Styliani Gerakari, Ilias C Papanikolaou, Prof Haralampos Milionis, Prof Markos Marangos, Prof George N Dalekos,

28 October, 2023

Impact of Single Nucleotide Polymorphisms of the Promoter of the TNF Gene on Adalimumab Treatment Responses in Hidradenitis Suppurativa

2023-10-28T20:24:17+03:00By hiss|Categories: Publications, Therapeutics|Tags: Adalimumab, Hidradenitis suppurativa|

Maria Argyropoulou, Anastasia Trigoni, Jessica Kaffenberger, Dimitra Stergianou, Georgia Damoraki, Elissavet Mingiani, Styliani Micha, Andrew Krispinsky, Parthena Meltzanidou, Theodora Kanni, Elizabeth Lazaridou, Evangelos J. Giamarellos-Bourboulis Dermatology (2023) 239 (5): 746–752 DOI: 10.1159/000531558Download pdf 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: Adalimumab, Hidradenitis

12 September, 2023

A randomized clinical trial of bermekimab treatment for clinical improvement of systemic sclerosis

2023-10-08T16:00:21+03:00By hiss|Categories: Publications, Therapeutics|Tags: bermekimab, clinical trial, systemic sclerosis|

Nicky Solomonidi, Panayiotis G. Vlachoyiannopoulos, Maria Pappa, Georgia Liantinioti, Sofia Ktena, Evangelos Theotikos, Antonia Elezoglou, Mihai G. Netea, and Evangelos J. Giamarellos-Bourboulis iScience 2023 Aug 19;26(9):107670 DOI: 10.1016/j.isci.2023.107670Download pdf 🡇 Funding The study was supported in part by the Hellenic Institute for the Study of Sepsis and in part by Janssen.

7 September, 2023

Immune responses of patients on maintenance hemodialysis after infection by SARS-CoV-2: a prospective observational cohort study

2023-09-07T17:24:36+03:00By hiss|Categories: Publications|Tags: COVID-19, cytokines|

Dimitra Bacharaki, Minas Karagiannis, Panagiotis Giannakopoulos, Evangelos Papachristou, Dimitrios Divanis, Aggeliki Sardeli, Dimitra Petrou, Petros Nikolopoulos, Adamantia Bratsiakou, Vassiliki Zoi, Nikitas Piliouras, Georgia Damoraki, Vassilios Liakopoulos, Dimitrios Goumenos and Evangelos J. Giamarellos-Bourboulis BMC Infectious Diseases (2023) 23:581 DOI: 10.1186/s12879-023-08569-2Download pdf 🡇 Funding The study was funded by the Hellenic Institute for

3 August, 2023

Sepsis, a call for inclusion in the work plan of the European Center for Disease Prevention and Control

2023-09-21T14:44:33+03:00By hiss|Categories: Publications|Tags: letter, Sepsis|

Evangelos J. Giamarellos-Bourboulis on behalf of the European Sepsis Alliance (ESA), Annelies S. Zinkernagel on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Edoardo De Robertis on behalf of the European Society of Anesthesiology and Intensive Care (ESAIC), Élie Azoulay on behalf of the European Society for Intensive Care Medicine

7 July, 2023

Analysis of inflammatory protein profiles in the circulation of COVID-19 patients identifies patients with severe disease phenotypes

2023-07-07T09:39:43+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19, phenotypes|

Nick Keur, Maria Saridaki, Isis Ricano-Ponce, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar Respiratory Medicine 2023 Jun 25; 217:107331 DOI: 10.1016/j.rmed.2023.107331Download pdf 🡇 Funding This work was funded by the ZonMw (10430012010002) to VK. The SAVE study was funded by the Hellenic Institute for the Study of Sepsis, Swedish Orphan