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15 February, 2023


2023-02-15T20:41:14+03:00By |Categories: Ongoing, Sepsis and severe infections, Studies|Tags: , |

Ongoing study Official Study Title A RANDOMIZED PROSPECTIVE CLINICAL TRIAL TO ASSESS PROCALCITONIN-GUIDANCE AND MOLECULAR-GUIDED DIAGNOSIS AS MAINSTAY FOR THERAPY OF SEVERE INFECTIONS (The MODIFY trial) Brief Description The aim of the study is to demonstrate if using a combined strategy of rapid molecular diagnosis with BioFire® FilmArray® Blood Culture Identification 2 Panel and

21 December, 2022

ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol

2023-02-16T12:30:26+03:00By |Categories: Publications, Therapeutics|Tags: , , |

Antigone Kotsaki, Peter Pickkers , Michael Bauer, Thierry Calandra, Mihaela Lupse, W Joost Wiersinga, Sylvain Meylan , Frank Bloos, Tom van der Poll, Marleen A Slim , Niels van Mourik, Marcella C A Müller, Lonneke van Vught,8 Alexander P J Vlaar, Aline de Nooijer, Lieke Bakkerus, Sebastian Weis, Nikolaos Antonakos, Mihai G Netea, Evangelos

1 November, 2022

Toward personalized immunotherapy in sepsis: The PROVIDE randomized clinical trial

2023-02-16T12:33:52+03:00By |Categories: Multicenter studies in Greece, Publications|Tags: , , |

Konstantinos Leventogiannis, Evdoxia Kyriazopoulou, Nikolaos Antonakos, Antigone Kotsaki, Iraklis Tsangaris, Dimitra Markopoulou, Inge Grondman, Nikoleta Rovina, Vassiliki Theodorou, Eleni Antoniadou, Ioannis Koutsodimitropoulos, George Dalekos, Glykeria Vlachogianni, Karolina Akinosoglou, Vassileios Koulouras, Apostolos Komnos, Theano Kontopoulou, Athanassios Prekates, Antonia Koutsoukou, Jos WM van der Meer, George Dimopoulos, Miltiades Kyprianou, Mihai G Netea, Evangelos J. Giamarellos-Bourboulis

1 September, 2022


2023-02-16T12:35:03+03:00By |Categories: Publications|Tags: |

Antigone Kotsaki, James W Wacker, Asimina Safarika, Nicky Solomonidi, Konstantinos Katsaros, George Giannikopoulos, Ioannis M Koutelidakis, Catherine A Hogan, Florian Uhle, Oliver Liesenfeld, Timothy E Sweeney, Evangelos J. Giamarellos-Bourboulis Shock 2022 Sep 1;58(3):224-230 DOI: 10.1097/SHK.0000000000001970 View article 🡇 Funding This study was supported in part by Inflammatix Inc. and

18 June, 2022

Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial

2023-02-16T12:38:06+03:00By |Categories: Publications|Tags: , , |

Eleni Karakike, Brendon P Scicluna, Maria Roumpoutsou, Ioannis Mitrou, Niki Karampela, Athanasios Karageorgos, Konstantinos Psaroulis, Eleni Massa, Achillefs Pitsoulis, Panagiotis Chaloulis, Evanthia Pappa, Irene T Schrijver, Frantzeska Frantzeskaki, Malvina Lada, Nicolas Dauby, David De Bels, Ioannis Floros, Souzana Anisoglou, Eleni Antoniadou, Maria Patrani, Glykeria Vlachogianni, Eleni Mouloudi, Anastasia Antoniadou, David Grimaldi, Thierry Roger, W

9 March, 2022

Antimicrobial Stewardship Using Biomarkers: Accumulating Evidence for the Critically Ill

2023-02-16T13:21:26+03:00By |Categories: Publications|Tags: , |

Evdoxia Kyriazopoulou, Evangelos J. Giamarellos-Bourboulis Antibiotics 2022 Mar 9;11(3):367 DOI: 10.3390/antibiotics11030367 View article 🡇 Funding This study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: C-reactive protein; COVID-19; ICU; antimicrobial stewardship; biomarker; guided antimicrobial therapy; infection; presepsin; procalcitonin; sepsis

25 February, 2022

Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure

2023-02-16T13:21:55+03:00By |Categories: Publications|Tags: , , |

Evangelos J. Giamarellos-Bourboulis, Garyfallia Poulakou, Aline de Nooijer, Haralampos Milionis, Simeon Metallidis, Michalis Ploumidis, Pinelopi Grigoropoulou, Aggeliki Rapti, Francesco Vladimiro Segala, Evangelos Balis, Efthymia Giannitsioti, Paola Rodari, Ilias Kainis, Zoi Alexiou, Emanuele Focà, Brollo Lucio, Nikoletta Rovina, Laura Scorzolini, Maria Dafni, Sofia Ioannou, Alessandro Tomelleri, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Christina

1 October, 2021

Cytokine production and outcome in MDR versus non-MDR gram-negative bacteraemia and sepsis

2023-02-16T13:23:33+03:00By |Categories: Epidemiology, Publications|Tags: |

Vasileios Karamouzos, Evangelos J. Giamarellos-Bourboulis, Dimitrios Velissaris, Theologia Gkavogianni and Charalambos Gogos Infectious Diseases 2021 Oct;53(10):764-771 DOI: 10.1080/23744235.2021.1925738View the article 🡇 Funding This work was funded by the Hellenic Institute for the study of sepsis. Keywords: Sepsis; cytokines; tumour necrosis factor-a; angiopoietin-2; multidrug resistance; carbapenem resistance

1 July, 2021


2023-03-22T16:41:34+03:00By |Categories: Interventional, Ongoing, Sepsis and severe infections, Studies|Tags: |

Ongoing study Official Study Title Personalized Immunotherapy in Sepsis: a multicentre and multinational, double-blind, double-dummy randomized clinical trial Brief Description Previous findings coming from the randomized clinical trial PROVIDE have showed that serum ferritin and expression of HLA-DR on circulating monocytes are reliable diagnostic markers of macrophage activation syndrome and of sepsis-induced immunoparalysis. The

18 June, 2021

A 29-mRNA host response test from blood accurately distinguishes bacterial and viral infections among emergency department patients

2023-02-16T13:25:09+03:00By |Categories: Multicenter studies in Greece, Publications|Tags: , |

Asimina Safarika, James W Wacker, Konstantinos Katsaros, Nicky Solomonidi, George Giannikopoulos, Antigone Kotsaki, Ioannis M Koutelidakis, Sabrina M Coyle, Henry K Cheng, Oliver Liesenfeld, Timothy E Sweeney, Evangelos J. Giamarellos-Bourboulis Intensive Care Medicine Experimental 2021 Jun 18;9(1):31 DOI: 10.1186/s40635-021-00394-8 View article 🡇 Funding The study was funded by Inflammatix.

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