Ongoing study Official Study Title A RANDOMIZED PROSPECTIVE CLINICAL TRIAL TO ASSESS PROCALCITONIN-GUIDANCE AND MOLECULAR-GUIDED DIAGNOSIS AS MAINSTAY FOR THERAPY OF SEVERE INFECTIONS (The MODIFY trial) Brief Description The aim of the study is to demonstrate if using a combined strategy of rapid molecular diagnosis with BioFire® FilmArray® Blood Culture Identification 2 Panel and
Antigone Kotsaki, Peter Pickkers , Michael Bauer, Thierry Calandra, Mihaela Lupse, W Joost Wiersinga, Sylvain Meylan , Frank Bloos, Tom van der Poll, Marleen A Slim , Niels van Mourik, Marcella C A Müller, Lonneke van Vught,8 Alexander P J Vlaar, Aline de Nooijer, Lieke Bakkerus, Sebastian Weis, Nikolaos Antonakos, Mihai G Netea, Evangelos
Konstantinos Leventogiannis, Evdoxia Kyriazopoulou, Nikolaos Antonakos, Antigone Kotsaki, Iraklis Tsangaris, Dimitra Markopoulou, Inge Grondman, Nikoleta Rovina, Vassiliki Theodorou, Eleni Antoniadou, Ioannis Koutsodimitropoulos, George Dalekos, Glykeria Vlachogianni, Karolina Akinosoglou, Vassileios Koulouras, Apostolos Komnos, Theano Kontopoulou, Athanassios Prekates, Antonia Koutsoukou, Jos WM van der Meer, George Dimopoulos, Miltiades Kyprianou, Mihai G Netea, Evangelos J. Giamarellos-Bourboulis
Antigone Kotsaki, James W Wacker, Asimina Safarika, Nicky Solomonidi, Konstantinos Katsaros, George Giannikopoulos, Ioannis M Koutelidakis, Catherine A Hogan, Florian Uhle, Oliver Liesenfeld, Timothy E Sweeney, Evangelos J. Giamarellos-Bourboulis Shock 2022 Sep 1;58(3):224-230 DOI: 10.1097/SHK.0000000000001970 View article 🡇 Funding This study was supported in part by Inflammatix Inc. and
Eleni Karakike, Brendon P Scicluna, Maria Roumpoutsou, Ioannis Mitrou, Niki Karampela, Athanasios Karageorgos, Konstantinos Psaroulis, Eleni Massa, Achillefs Pitsoulis, Panagiotis Chaloulis, Evanthia Pappa, Irene T Schrijver, Frantzeska Frantzeskaki, Malvina Lada, Nicolas Dauby, David De Bels, Ioannis Floros, Souzana Anisoglou, Eleni Antoniadou, Maria Patrani, Glykeria Vlachogianni, Eleni Mouloudi, Anastasia Antoniadou, David Grimaldi, Thierry Roger, W
Evdoxia Kyriazopoulou, Evangelos J. Giamarellos-Bourboulis Antibiotics 2022 Mar 9;11(3):367 DOI: 10.3390/antibiotics11030367 View article 🡇 Funding This study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: C-reactive protein; COVID-19; ICU; antimicrobial stewardship; biomarker; guided antimicrobial therapy; infection; presepsin; procalcitonin; sepsis
Evangelos J. Giamarellos-Bourboulis, Garyfallia Poulakou, Aline de Nooijer, Haralampos Milionis, Simeon Metallidis, Michalis Ploumidis, Pinelopi Grigoropoulou, Aggeliki Rapti, Francesco Vladimiro Segala, Evangelos Balis, Efthymia Giannitsioti, Paola Rodari, Ilias Kainis, Zoi Alexiou, Emanuele Focà, Brollo Lucio, Nikoletta Rovina, Laura Scorzolini, Maria Dafni, Sofia Ioannou, Alessandro Tomelleri, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Christina
Vasileios Karamouzos, Evangelos J. Giamarellos-Bourboulis, Dimitrios Velissaris, Theologia Gkavogianni and Charalambos Gogos Infectious Diseases 2021 Oct;53(10):764-771 DOI: 10.1080/23744235.2021.1925738View the article 🡇 Funding This work was funded by the Hellenic Institute for the study of sepsis. Keywords: Sepsis; cytokines; tumour necrosis factor-a; angiopoietin-2; multidrug resistance; carbapenem resistance
Ongoing study Official Study Title Personalized Immunotherapy in Sepsis: a multicentre and multinational, double-blind, double-dummy randomized clinical trial Brief Description Previous findings coming from the randomized clinical trial PROVIDE have showed that serum ferritin and expression of HLA-DR on circulating monocytes are reliable diagnostic markers of macrophage activation syndrome and of sepsis-induced immunoparalysis. The
Asimina Safarika, James W Wacker, Konstantinos Katsaros, Nicky Solomonidi, George Giannikopoulos, Antigone Kotsaki, Ioannis M Koutelidakis, Sabrina M Coyle, Henry K Cheng, Oliver Liesenfeld, Timothy E Sweeney, Evangelos J. Giamarellos-Bourboulis Intensive Care Medicine Experimental 2021 Jun 18;9(1):31 DOI: 10.1186/s40635-021-00394-8 View article 🡇 Funding The study was funded by Inflammatix.