hiss, Author at HISS

1 February, 2018

Haplotypes composed of minor frequency single nucleotide polymorphisms of the TNF gene protect from progression into sepsis: A study using the new sepsis classification

2024-03-28T17:04:25+03:00By hiss|Categories: Genetics, Publications|Tags: genetics, Sepsis|

Theodoros Retsas, Klaus Huse, Lazaros-Dimitrios Lazaridis, Niki Karampela, Michael Bauer, Matthias Platzer, Virginia Kolonia, Eirini Papageorgiou, Evangelos J. Giamarellos-Bourboulis, George Dimopoulos International Journal of Infectious Diseases 2018 Feb;67:102-106 DOI: 10.1016/j.ijid.2017.12.008Download pdf 🡇 FundingThe study was funded in part by the Hellenic Institute for the Study of Sepsis and by the Federal Ministry of

1 December, 2017

PROVIDE

2024-10-18T11:36:45+03:00By hiss|Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: Anakinra, Sepsis|

Completed study Official Study Title A Personalized Randomized Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis (PROVIDE) Brief Description PROVIDE is a randomized clinical trial aiming to the personalized therapy of patients at septic shock. Using biomarkers, enrolled patients are randomized through a double-dummy approach to immunotherapy or placebo

1 December, 2017

ACTIVATE

2023-01-16T00:13:56+03:00By hiss|Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: BCG|

Completed study Official Study Title A randomized Clinical Trial for enhanced trained Immune responses through bacillus calmette-guérin VAccination to prevenT infections of the Elderly (ACTIVATE) Brief Description ACTIVATE is a randomized clinical trial aiming to investigate if the developing concept of trained immunity i.e. the memory of the innate immune system coming after vaccination

1 December, 2017

INCLASS

2023-01-09T12:15:00+03:00By hiss|Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: clarithromycin, Sepsis|

Completed study Official Study Title A double-blind, randomized, placebo-controlled clinical study of the efficacy of INtravenous CLArithromycin as adjunctive treatment in patients with Sepsis and respiratory and multiple organ dysfunction Syndrome Brief Description INCLASS is a randomized clinical trial aiming to compare the efficacy of intravenous clarithromycin over placebo in patients with sepsis and

1 December, 2017

Platelet reactivity in sepsis syndrome: results from the PRESS study

2023-02-16T15:08:41+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Sepsis|

Karolina Akinosoglou, Spyridoula Theodoraki, Ioanna Xanthopoulou, Angelos Perperis, Theologia Gkavogianni, Aikaterini Pistiki, Evangelos J Giamarellos-Bourboulis, Charalambos A Gogos European Journal of Clinical Microbiology & Infectious Diseases 2017 Dec;36(12):2503-2512 DOI: 10.1007/s10096-017-3093-6View the article 🡇 Funding This work was funded by the Hellenic Institute for the Study of Sepsis. Keywords: Organ dysfunction; P2Y12 platelet

1 November, 2017

Lipid peroxidation in Gram-negative bacteremia modulates the risk for septic shock and infections by resistant Klebsiella pneumoniae

2023-02-16T15:10:33+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Sepsis|

S Christodoulou, E Kyriazopoulou, M Chrysanthakopoulou, G Karlis, I Karampela, K Gkizeli, N Veliki, A Safarika, E J Giamarellos-Bourboulis, G Adamis; Hellenic Sepsis Study Group European Journal of Clinical Microbiology & Infectious Diseases 2017 Nov;36(11):2171-2177 DOI: 10.1007/s10096-017-3041-5View article 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis.

1 October, 2017

INTELLIGENCE-1

2023-01-09T12:10:28+03:00By hiss|Categories: Completed, Non-Interventional, Sepsis and severe infections, Studies|Tags: Sepsis|

Completed study Official Study Title INTEgration of clinicaL and Laboratory Information to GENerate technological advanCE for the diagnosis of sepsis Brief Description INTELLIGENCE-1 is a non-interventional trial to validate the diagnostic accuracy of HemoSpec in the diagnosis of sepsis. HemoSpec is a device that integrates information of whole blood cell count, Raman spectra of

1 October, 2017

PROGRESS

2025-05-12T15:07:31+03:00By hiss|Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: procalcitonin, Sepsis|

Completed study Official Study Title A randomized prospective clinical trial to assess the role of PROcalcitonin-Guided antimicrobial therapy to REduce long-term infectionS Sequelae Brief Description PROGRESS is a randomized clinical trial aiming to test the efficacy of an algorithm of the duration of antimicrobial treatment based on serum procalcitonin in patients with sepsis on

1 October, 2017

Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction

2023-02-16T15:11:50+03:00By hiss|Categories: Biomarkers, Publications|Tags: Sepsis|

Aikaterini Ioakeimidou, E Pagalou, Marina Kontogiorgi, Eleni Antoniadou, Katerina Kaziani, Konstantinos Psaroulis, Evangelos J. Giamarellos-Bourboulis, Athanasios Prekates, Nikolaos Antonakos, P Lassale, Charalambos Gogos; Hellenic Sepsis Study Group European Journal of Clinical Microbiology & Infectious Diseases 2017 Oct;36(10):1749-1756 DOI: 10.1007/s10096-017-2988-6View article 🡇 Funding The study was funded by the Hellenic Institute for the Study

18 September, 2017

Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis

2024-03-28T16:56:33+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Sepsis|

Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Anna Norrby-Teglund, Georgios Dimopoulos, Aikaterini Pantazi, Stylianos E. Orfanos, Nikoletta Rovina, Iraklis Tsangaris, Theologia Gkavogianni, Elektra Botsa, Eleftheria Chassiou, Anastasia Kotanidou, Christina Kontouli, Panagiotis Chaloulis, Dimitrios Velissaris, Athina Savva, Jonas-Sundén Cullberg, Karolina Akinosoglou, Charalambos Gogos, Apostolos Armaganidis, Evangelos J. Giamarellos-Bourboulis on behalf of the Hellenic Sepsis Study Group BMC

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