Publications

7 July, 2023

Analysis of inflammatory protein profiles in the circulation of COVID-19 patients identifies patients with severe disease phenotypes

2023-07-07T09:39:43+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19, phenotypes|

Nick Keur, Maria Saridaki, Isis Ricano-Ponce, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar Respiratory Medicine 2023 Jun 25; 217:107331 DOI: 10.1016/j.rmed.2023.107331Download pdf 🡇 Funding This work was funded by the ZonMw (10430012010002) to VK. The SAVE study was funded by the Hellenic Institute for the Study of Sepsis, Swedish Orphan

9 March, 2023

Presepsin as a diagnostic and prognostic biomarker of severe bacterial infections and COVID‑19

2023-03-09T12:07:30+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19|

Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Georgios Tavoulareas, Efstratios Mainas, Konstantinos Toutouzas, Christos Mathas, Athanassios Prekates, Vissaria Sakka, Periklis Panagopoulos, Konstantinos Syrigos & Evangelos J. Giamarellos-Bourboulis Scientific Reports 13, Article number: 3814 (2023) DOI: 10.1038/s41598-023-30807-5Download pdf 🡇 Funding The study was funded in part by the FrameWork 7 project HemoSpec (Grant 611682) and in part

10 February, 2023

Case report: The devil was hidden in the mastocytes – an unusually fulminant case of indolent systemic mastocytosis in a 45-year-old patient, missed for almost 20 years

2023-02-16T12:24:58+03:00By hiss|Categories: Epidemiology, Publications|

Aristeidis E. Boukouris, Ioannis Michelakis, Dionysios Metaxas, Gianna Karapati, George Kanellis, Athina Lioni, Vasiliki Tzavara Frontiers Immunology, 14:1134587 DOI: 10.1111/cea.12318Download pdf 🡇 Funding This study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: Case report

27 December, 2022

Efficacy and safety of early soluble urokinase plasminogen receptor plasma-guided anakinra treatment of COVID-19 pneumonia: A subgroup analysis of the SAVE-MORE randomised trial

2024-04-03T12:43:50+03:00By hiss|Categories: Publications, Therapeutics|Tags: Anakinra, clinical trial, COVID-19, suPAR|

Karolina Akinosoglou, Antigone Kotsaki, Ioanna-Maria Gounaridi, Eirini Christaki, Simeon Metallidis, Georgios Adamis, Archontoula Fragkou, Massimo Fantoni, Aggeliki Rapti, Ioannis Kalomenidis, Georgios Chrysos, Gloria Boni, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Asimina Safarika, Sofia Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios

27 December, 2022

Oral minocycline plus rifampicin versus oral linezolid for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: The AIDA open label, randomized, controlled Phase 4 trial

2024-04-03T12:38:22+03:00By hiss|Categories: Publications, Therapeutics|Tags: clinical trial, skin infections|

Antigone Kotsaki, Nikolaos Tziolos, Theano Kontopoulou, Ioannis M. Koutelidakis, Styliani Symbardi, Vaughan Reed, Miriam O’Hare, Zoi Alexiou, Helen Sambatakou, Konstantinos Toutouzas, Karolina Akinosoglou, Malvina Lada, Evangelos J. Giamarellos-Bourboulis, and Alasdair MacGowan eClinicalMedicine Volume 56, 101790, February 01, 2023 DOI: 10.1016/j.eclinm.2022.101790Download pdf 🡇 Funding The EU Seventh Research Framework Programme. Keywords: Minocycline; Rifampicin;

21 December, 2022

ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol

2024-04-02T18:40:49+03:00By hiss|Categories: Publications, Therapeutics|Tags: clinical trial, Sepsis, SOFA|

Antigone Kotsaki, Peter Pickkers , Michael Bauer, Thierry Calandra, Mihaela Lupse, W Joost Wiersinga, Sylvain Meylan , Frank Bloos, Tom van der Poll, Marleen A Slim , Niels van Mourik, Marcella C A Müller, Lonneke van Vught,8 Alexander P J Vlaar, Aline de Nooijer, Lieke Bakkerus, Sebastian Weis, Nikolaos Antonakos, Mihai G Netea, Evangelos

19 December, 2022

Interferon gamma-induced protein 10 (IP-10) for the early prognosis of the risk for severe respiratory failure and death in COVID-19 pneumonia

2024-04-02T18:36:36+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Anakinra, clinical trial, COVID-19|

Charilaos Samaras, Evdoxia Kyriazopoulou, Garyfallia Poulakou, Eran Reiner, Maria Kosmidou, Ioanna Karanika, Vasileios Petrakis, George Adamis, Nikolaos K. Gatselis, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, George Chrysos, Giulia Bertoli, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Evangelos Kostis, Lorenzo Dagna, Sofia Koukidou, Glykeria Tzatzagou,

7 November, 2022

A randomized clinical trial of lipid metabolism modulation with fenofibrate for acute coronavirus disease 2019

2023-02-16T12:33:18+03:00By hiss|Categories: Publications|Tags: clinical trial, COVID-19, metabolism|

Julio A Chirinos, Patricio Lopez-Jaramillo, Evangelos J. Giamarellos-Bourboulis, Gonzalo H Dávila-Del-Carpio, Abdul Rahman Bizri, Jaime F Andrade-Villanueva, Oday Salman, Carlos Cure-Cure, Nelson R Rosado-Santander, Mario P Cornejo Giraldo, Luz A González-Hernández, Rima Moghnieh, Rapti Angeliki, María E Cruz Saldarriaga, Marcos Pariona, Carola Medina, Ioannis Dimitroulis, Charalambos Vlachopoulos, Corina Gutierrez, Juan E Rodriguez-Mori, Edgar Gomez-Laiton,

1 November, 2022

Toward personalized immunotherapy in sepsis: The PROVIDE randomized clinical trial

2024-04-02T18:31:09+03:00By hiss|Categories: Multicenter studies in Greece, Publications|Tags: Anakinra, clinical trial, Sepsis|

Konstantinos Leventogiannis, Evdoxia Kyriazopoulou, Nikolaos Antonakos, Antigone Kotsaki, Iraklis Tsangaris, Dimitra Markopoulou, Inge Grondman, Nikoleta Rovina, Vassiliki Theodorou, Eleni Antoniadou, Ioannis Koutsodimitropoulos, George Dalekos, Glykeria Vlachogianni, Karolina Akinosoglou, Vassileios Koulouras, Apostolos Komnos, Theano Kontopoulou, Athanassios Prekates, Antonia Koutsoukou, Jos WM van der Meer, George Dimopoulos, Miltiades Kyprianou, Mihai G Netea, Evangelos J. Giamarellos-Bourboulis

1 September, 2022

A 29-MRNA HOST RESPONSE WHOLE-BLOOD SIGNATURE IMPROVES PREDICTION OF 28-DAY MORTALITY AND 7-DAY INTENSIVE CARE UNIT CARE IN ADULTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH SUSPECTED ACUTE INFECTION AND/OR SEPSIS

2023-02-16T12:35:03+03:00By hiss|Categories: Publications|Tags: Sepsis|

Antigone Kotsaki, James W Wacker, Asimina Safarika, Nicky Solomonidi, Konstantinos Katsaros, George Giannikopoulos, Ioannis M Koutelidakis, Catherine A Hogan, Florian Uhle, Oliver Liesenfeld, Timothy E Sweeney, Evangelos J. Giamarellos-Bourboulis Shock 2022 Sep 1;58(3):224-230 DOI: 10.1097/SHK.0000000000001970 View article 🡇 Funding This study was supported in part by Inflammatix Inc. and