Publications

9 March, 2022

Antimicrobial Stewardship Using Biomarkers: Accumulating Evidence for the Critically Ill

2023-02-16T13:21:26+03:00By hiss|Categories: Publications|Tags: COVID-19, Sepsis|

Evdoxia Kyriazopoulou, Evangelos J. Giamarellos-Bourboulis Antibiotics 2022 Mar 9;11(3):367 DOI: 10.3390/antibiotics11030367 View article 🡇 Funding This study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: C-reactive protein; COVID-19; ICU; antimicrobial stewardship; biomarker; guided antimicrobial therapy; infection; presepsin; procalcitonin; sepsis

25 February, 2022

Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure

2023-02-16T13:21:55+03:00By hiss|Categories: Publications|Tags: COVID-19, Sepsis, suPAR|

Evangelos J. Giamarellos-Bourboulis, Garyfallia Poulakou, Aline de Nooijer, Haralampos Milionis, Simeon Metallidis, Michalis Ploumidis, Pinelopi Grigoropoulou, Aggeliki Rapti, Francesco Vladimiro Segala, Evangelos Balis, Efthymia Giannitsioti, Paola Rodari, Ilias Kainis, Zoi Alexiou, Emanuele Focà, Brollo Lucio, Nikoletta Rovina, Laura Scorzolini, Maria Dafni, Sofia Ioannou, Alessandro Tomelleri, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Christina

1 December, 2021

Early Start of Oral Clarithromycin Is Associated with Better Outcome in COVID-19 of Moderate Severity: The ACHIEVE Open-Label Single-Arm Trial

2023-02-16T13:22:30+03:00By hiss|Categories: Publications|Tags: clarithromycin, clinical trial, COVID-19|

Konstantinos Tsiakos, Antonios Tsakiris, Georgios Tsibris, Pantazis-Michael Voutsinas, Periklis Panagopoulos, Maria Kosmidou, Vasileios Petrakis, Areti Gravvani, Theologia Gkavogianni, Eleftherios Klouras, Konstantina Katrini, Panagiotis Koufargyris, Iro Rapti, Athanassios Karageorgos, Emmanouil Vrentzos, Christina Damoulari, Vagia Zarkada, Chrysanthi Sidiropoulou, Sofia Artemi, Anastasios Ioannidis, Androniki Papapostolou, Evangelos Michelakis, Maria Georgiopoulou, Dimitra-Melia Myrodia, Panteleimon Tsiamalos, Konstantinos Syrigos, George Chrysos,

1 October, 2021

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

2024-04-02T18:13:24+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: Anakinra, clinical trial, COVID-19|

Evdoxia Kyriazopoulou, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Georgios Adamis, Konstantinos Tsiakos, Archontoula Fragkou, Aggeliki Rapti, Christina Damoulari, Massimo Fantoni, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Maria Tsilika, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Evangelos Kostis, Lorenzo Dagna, Panagiotis Koufargyris, Katerina Dimakou, Spyridon Savvanis, Glykeria

1 October, 2021

Cytokine production and outcome in MDR versus non-MDR gram-negative bacteraemia and sepsis

2023-02-16T13:23:33+03:00By hiss|Categories: Epidemiology, Publications|Tags: Sepsis|

Vasileios Karamouzos, Evangelos J. Giamarellos-Bourboulis, Dimitrios Velissaris, Theologia Gkavogianni and Charalambos Gogos Infectious Diseases 2021 Oct;53(10):764-771 DOI: 10.1080/23744235.2021.1925738View the article 🡇 Funding This work was funded by the Hellenic Institute for the study of sepsis. Keywords: Sepsis; cytokines; tumour necrosis factor-a; angiopoietin-2; multidrug resistance; carbapenem resistance

1 September, 2021

The Role of Macrolides for the Management of Community-Acquired Pneumonia and Pneumonia by the Novel Coronavirus SARS-CoV-2 (COVID-19): A Position Paper by Four Medical Societies from Greece

2024-04-02T18:01:32+03:00By hiss|Categories: Publications, Therapeutics|Tags: clarithromycin, COVID-19, pneumonia|

Evangelos J. Giamarellos-Bourboulis, George L Daikos, Panagiotis Gargalianos, Charalambos Gogos, Marios Lazanas, Periklis Panagopoulos, Garyphallia Poulakou, Helen Sambatakou, Michael Samarkos Infectious Diseases and Therapy 2021 Sep;10(3):1081-1095 DOI: 10.1007/s40121-021-00471-1Download pdf 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis. No Rapid Service Fee was received by the

1 September, 2021

BioFire® FilmArray® Pneumonia Panel for Severe Lower Respiratory Tract Infections: Subgroup Analysis of a Randomized Clinical Trial

2024-04-01T07:35:21+03:00By hiss|Categories: Biomarkers, Multicenter studies in Greece, Publications|Tags: clinical trial, procalcitonin|

Evdoxia Kyriazopoulou, Athanasios Karageorgos, Lydia Liaskou-Antoniou, Panagiotis Koufargyris, Asimina Safarika, Georgia Damoraki, Vasileios Lekakis, Maria Saridaki, George Adamis, Evangelos J. Giamarellos-Bourboulis Infectious Diseases and Therapy 2021 Sep;10(3):1437-1449 DOI: 10.1007/s40121-021-00459-xDownload pdf 🡇 Funding The PROGRESS trial was supported by grants by the Hellenic Institute for the Study of Sepsis and by bioMérieux, Lyon,

1 July, 2021

Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19)

2024-04-01T07:28:20+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19|

Maria Saridaki, Simeon Metallidis, Sotiria Grigoropoulou, Emmanouil Vrentzos, Malvina Lada, Katerina Argyraki, Olga Tsachouridou, Anna Georgiadou, Anil Vasishta, Evangelos J. Giamarellos-Bourboulis European Journal of Clinical Microbiology & Infectious Diseases 2021 Jul;40(7):1405-1412 DOI: 10.1007/s10096-020-04145-7Download pdf 🡇 Funding The study was funded in part by the Hellenic Institute for the Study of Sepsis and

18 June, 2021

A 29-mRNA host response test from blood accurately distinguishes bacterial and viral infections among emergency department patients

2023-02-16T13:25:09+03:00By hiss|Categories: Multicenter studies in Greece, Publications|Tags: clinical trial, Sepsis|

Asimina Safarika, James W Wacker, Konstantinos Katsaros, Nicky Solomonidi, George Giannikopoulos, Antigone Kotsaki, Ioannis M Koutelidakis, Sabrina M Coyle, Henry K Cheng, Oliver Liesenfeld, Timothy E Sweeney, Evangelos J. Giamarellos-Bourboulis Intensive Care Medicine Experimental 2021 Jun 18;9(1):31 DOI: 10.1186/s40635-021-00394-8 View article 🡇 Funding The study was funded by Inflammatix.

1 May, 2021

Differential response induced by LPS and MPLA in immunocompetent and septic individuals

2023-02-16T13:25:47+03:00By hiss|Categories: Publications, Sepsis and severe infections|Tags: clinical trial, Sepsis|

Chloé Albert Vega, Eleni Karakike, François Bartolo, William Mouton, Elisabeth Cerrato, Karen Brengel-Pesce, Evangelos J. Giamarellos-Bourboulis, François Mallet, Sophie Trouillet-Assant Clinical Immunology 2021 May;226:108714 DOI: 10.1016/j.clim.2021.108714 View article 🡇 Funding This work was supported by Marie Sklodowska-Curie Innovative Training H2020-MSCA-ITN-2015, under the grant agreement No 676129. Keywords: Immune functional