Patrick Möhnle, Simon Hirschberger, Ludwig Christian Giuseppe Hinske, Josef Briegel, Max Hübner, Sebastien Weis, Georgios Dimopoulos, Michael Bauer, Evangelos J. Giamarellos-Bourboulis, Simone Kreth

MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis

Molecular Medicine 2018 Oct 17;24(1):54
DOI: 10.1186/s10020-018-0056-zDownload pdf 🡇


This work has been funded by the Charles-Evans-Foundation, New Jersey, USA. Sebastian Weis and Michael Bauer are supported by the Integrated Research and Treatment Center – Center for Sepsis Control and Care (CSCC) at the Jena University Hospital. The CSCC is funded by the German Ministry of Education and Research (BMBF No. 01EO1002; 01EO1502). The collection of the Greek cohort was funded by the Hellenic Institute for the Study of Sepsis. The sponsors had no role in study design or collection, analysis and interpretation of data, nor in writing or submission of this manuscript.

Keywords: Biomarker; Immunoparalysis; Sepsis; T cell exhaustion; T-cells; miRNA