COVID-19

25 September, 2024

HEPARIN-BINDING PROTEIN LEVELS PREDICT UNFAVORABLE OUTCOME IN COVID-19 PNEUMONIA: A POST HOC ANALYSIS OF THE SAVE TRIAL

2024-10-18T12:27:27+03:00By hiss|Categories: Biomarkers, Multicenter studies in Greece, Publications|Tags: COVID-19, heparin-binding protein, mortality, pneumonia|

Evdoxia Kyriazopoulou , George N Dalekos, Symeon Metallidis, Garyphalia Poulakou, Ilias C Papanikolaou, Vasiliki Tzavara, Katerina Argyraki, Zoi Alexiou, Periklis Panagopoulos, Michael Samarkos, George Chrysos, Aikaterini Tseliou, Haralampos Milionis, Styliani Sympardi, Anil Vasishta, Evangelos J. Giamarellos-Bourboulis Shock 2024 Mar 1;61(3):395-399. DOI: 10.1097/SHK.0000000000002315View article 🡆 Funding This study was supported in part

17 September, 2024

Clinical Phenotyping for Prognosis and Immunotherapy Guidance in Bacterial Sepsis and COVID-19

2024-10-18T11:44:36+03:00By hiss|Categories: Genetics, Publications|Tags: COVID-19, phenotypes, Sepsis|

Eleni Karakike, Simeon Metallidis, Garyfallia Poulakou, Maria Kosmidou, Nikolaos K. Gatselis, Vasileios Petrakis, Nikoletta Rovina, Eleni Gkeka, Styliani Sympardi, Ilias Papanikolaou, Ioannis Koutsodimitropoulos, Vasiliki Tzavara, Georgios Adamis, Konstantinos Tsiakos, Vasilios Koulouras, Eleni Mouloudi, Eleni Antoniadou, Gykeria Vlachogianni, Souzana Anisoglou, Nikolaos Markou, Antonia Koutsoukou, Periklis Panagopoulos, Haralampos Milionis, George N. Dalekos, Miltiades Kyprianou, Evangelos J.

14 March, 2024

Transitions of blood immune endotypes and improved outcome by anakinra in COVID-19 pneumonia: an analysis of the SAVE-MORE randomized controlled trial

2024-03-14T14:03:07+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Anakinra, clinical trial, COVID-19, Sepsis|

Evdoxia Kyriazopoulou, Yehudit Hasin‐Brumshtein, Uros Midic, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Myrto Astriti, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vasiliki Tzavara, Sofa Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios

5 January, 2024

Association of Vitamin D with Severity and Outcome of COVID-19: Clinical and Experimental Evidence

2024-01-05T14:33:18+03:00By hiss|Categories: Biomarkers, Publications|Tags: ARDS, COVID-19|

Georgios Renieris, Spyros Foutadakis, Theano Andriopoulou, Victoria-Marina Spanou, Dionyssia-Eirini Droggiti, Dionysios Kafousopoulos , Theologia Gkavogianni, Georgia Damoraki, Giannis Vatsellas, Evangelos J. Giamarellos-Bourboulis J Innate Immun (2023) 16 (1): 1–11DOI: 10.1159/000535302Download pdf 🡇 FundingThe study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: Vitamin D; Tumor necrosis factor; Interleukin-6; Interferon gamma;

7 September, 2023

Immune responses of patients on maintenance hemodialysis after infection by SARS-CoV-2: a prospective observational cohort study

2023-09-07T17:24:36+03:00By hiss|Categories: Publications|Tags: COVID-19, cytokines|

Dimitra Bacharaki, Minas Karagiannis, Panagiotis Giannakopoulos, Evangelos Papachristou, Dimitrios Divanis, Aggeliki Sardeli, Dimitra Petrou, Petros Nikolopoulos, Adamantia Bratsiakou, Vassiliki Zoi, Nikitas Piliouras, Georgia Damoraki, Vassilios Liakopoulos, Dimitrios Goumenos and Evangelos J. Giamarellos-Bourboulis BMC Infectious Diseases (2023) 23:581 DOI: 10.1186/s12879-023-08569-2Download pdf 🡇 Funding The study was funded by the Hellenic Institute for

1 September, 2023

PRECISION

2024-12-11T10:32:19+03:00By hiss|Categories: Interventional, Ongoing, Sepsis and severe infections, Studies|Tags: Anakinra, COVID-19|

HISS: Facing the LONG-COVID syndrome Ongoing study Official Study Title Safety and efficacy of Anakinra treatment for patients with Persistent REspiratory symptoms post-acute COVID and Immune System activatION: the PRECISION double-blind, randomized clinical trial Brief Description The effect of the drug anakinra in the treatment of long-term complications after COVID-19. The

7 July, 2023

Analysis of inflammatory protein profiles in the circulation of COVID-19 patients identifies patients with severe disease phenotypes

2023-07-07T09:39:43+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19, phenotypes|

Nick Keur, Maria Saridaki, Isis Ricano-Ponce, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar Respiratory Medicine 2023 Jun 25; 217:107331 DOI: 10.1016/j.rmed.2023.107331Download pdf 🡇 Funding This work was funded by the ZonMw (10430012010002) to VK. The SAVE study was funded by the Hellenic Institute for the Study of Sepsis, Swedish Orphan

9 March, 2023

Presepsin as a diagnostic and prognostic biomarker of severe bacterial infections and COVID‑19

2023-03-09T12:07:30+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19|

Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Georgios Tavoulareas, Efstratios Mainas, Konstantinos Toutouzas, Christos Mathas, Athanassios Prekates, Vissaria Sakka, Periklis Panagopoulos, Konstantinos Syrigos & Evangelos J. Giamarellos-Bourboulis Scientific Reports 13, Article number: 3814 (2023) DOI: 10.1038/s41598-023-30807-5Download pdf 🡇 Funding The study was funded in part by the FrameWork 7 project HemoSpec (Grant 611682) and in part

10 January, 2023

SAVE-LONG

2023-05-22T14:50:00+03:00By hiss|Categories: Non-Interventional, Ongoing, Sepsis and severe infections, Studies|Tags: COVID-19|

Ongoing study Official Study Title Symptom-guided Anakinra treatment for the Validation of immunE dysfunction persisting for LONG after hospital discharge for COVID-19 (SAVE-LONG) Brief Description SAVE-LONG is a call to the development of diagnostic tools and therapeutic modalities for patients with Long-COVID Syndrome. Details Status: ongoing Study Type: Non-interventional Study phase: II &

27 December, 2022

Efficacy and safety of early soluble urokinase plasminogen receptor plasma-guided anakinra treatment of COVID-19 pneumonia: A subgroup analysis of the SAVE-MORE randomised trial

2024-04-03T12:43:50+03:00By hiss|Categories: Publications, Therapeutics|Tags: Anakinra, clinical trial, COVID-19, suPAR|

Karolina Akinosoglou, Antigone Kotsaki, Ioanna-Maria Gounaridi, Eirini Christaki, Simeon Metallidis, Georgios Adamis, Archontoula Fragkou, Massimo Fantoni, Aggeliki Rapti, Ioannis Kalomenidis, Georgios Chrysos, Gloria Boni, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Asimina Safarika, Sofia Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios