Sepsis

1 September, 2025

An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis

2025-09-06T11:28:43+03:00By hiss|Categories: Biomarkers, Publications|Tags: diagnosis, Sepsis|

Pinzauti David, Biazzo Manuele, Podrini Christine, Alevizou Antonia, Safarika Asimina, Damoraki Georgia, Koufargyris Panagiotis, Tasouli Elisavet, Skopelitis Ilias, Poulakou Garyfallia, Sympardi Styliani and Evangelos J. Giamarellos-Bourboulis Front. Cell. Infect. Microbiol. 15:1656171 DOI: 10.3389/fcimb.2025.1656171Download pdf 🡇 Funding The author(s) declare financial support was received for the research and/or publication of this article. The

9 August, 2025

Biomarkers to guide sepsis management

2025-08-22T19:16:30+03:00By hiss|Categories: Biomarkers, Publications|Tags: Sepsis|

Vasiliki Bourika, Evangelia-Areti Rekoumi and Evangelos J. Giamarellos-Bourboulis Ann Intensive Care. 2025 Jul 21;15(1):103 DOI: 10.1186/s13613-025-01524-1Download pdf 🡇 Funding No funding was provided for this manuscript. Keywords: Sepsis, Biomarkers, Guidance, Antibiotics, Fluids, Vasopressors

1 July, 2025

29-mRNA host response signatures for classifcation of bacterial infection, viral infection and disease progression in COVID-19 pneumonia: a post hoc analysis of the SAVE-MORE randomized clinical trial

2025-07-01T22:02:55+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19, infection, pneumonia, Sepsis|

Evdoxia Kyriazopoulou, Antigone Kotsaki, Asimina Safarika, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Georgios Adamis, Archontoula Fragkou, Aggeliki Rapti, Pierluigi Del Vecchio, Ioannis Kalomenidis, Danae Kitzoglou, Andrea Angheben, Ilias Kainis, Konstantina Iliopoulou, Francesco Saverio Serino, Petros Bakakos, Vassiliki Tzavara, Sofa Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassett, Vasileios Kotsis, George Tsoukalas,

12 May, 2025

Procalcitonin-guided early cessation of antibiotics prevents gut inflammation and preserves gut microbiome: Data from the PROGRESS controlled trial

2025-05-12T15:05:05+03:00By hiss|Categories: Biomarkers, Publications|Tags: microbiome, procalcitonin, Sepsis|

Evdoxia Kyriazopoulou, Emmanouil Stylianakis, Georgia Damoraki, Panagiotis Koufargyris, Ioannis Kollias, Konstantina Katrini, Elina Drakou, Konstantinos Marousis, Andronikos Spyrou, Styliani Symbardi, Nikolaos Alexiou, Zoi Alexiou, Malvina Lada, Garyfallia Poulakou, Georgios Chrysos, George Adamis, Evangelos J. Giamarellos-Bourboulis Int J Antimicrob Agents. 2025 Apr 9:107507 DOI: 10.1016/j.ijantimicag.2025.107507 View article 🡆 FundingHellenic Institute for the Study of Sepsis

12 March, 2025

EMBRACE

2025-07-15T11:54:45+03:00By hiss|Categories: Interventional, Ongoing, Sepsis and severe infections, Studies|Tags: emapalumab, IFNγ, infections, Sepsis|

Ongoing study Official Study Title EMapalumaB treatment foR Anticipated Clinical benefit in sepsis driven by the Interferon-Gamma Endotype (The EMBRACE trial) Brief Description In a recent analysis of 5,503 patients with sepsis meeting the Sepsis-3 definitions and coming from Germany, Greece and Italy randomized into one discovery set and one validation set, it was

26 February, 2025

Recent advances of precision immunotherapy in sepsis

2025-03-10T10:51:58+03:00By hiss|Categories: Publications|Tags: Anakinra, Interferon-gamma, Sepsis|

Antonios Arapis, Dimitrios Panagiotopoulos, Evangelos J. Giamarellos-Bourboulis Burns & Trauma, 2025, 13, tkaf001 DOI: 10.1093/burnst/tkaf001Download pdf 🡇 Keywords: Precision immunotherapy; Sepsis; Anakinra; Nangibotide; Nivolumab; Interferon-gamma; Growth factors; Adrecizumab

25 October, 2024

Interferon-gamma driven elevation of CXCL9: a new sepsis endotype independently associated with mortality

2024-10-25T09:53:56+03:00By hiss|Categories: Biomarkers, Publications|Tags: Interferon-gamma, mortality, Sepsis|

Evangelos J. Giamarellos-Bourboulis, Massimo Antonelli, Frank Bloos, Ioanna Kotsamidi, Christos Psarrakis, Konstantina Dakou, Daniel Thomas-Rüddel, Luca Montini, Josef Briegel, Georgia Damoraki, Panagiotis Koufargyris, Souzana Anisoglou, Eleni Antoniadou, Glykeria Vlachogianni, Christos Tsiantas, Matteo Masullo, Aikaterini Ioakeimidou, Eumorfia Kondili, Maria Ntaganou, Eleni Gkeka, Vassileios Papaioannou, Effie Polyzogopoulou, Armin J Reininger, Gennaro De Pascale, Michael Kiehntopf, Eleni

17 September, 2024

Clinical Phenotyping for Prognosis and Immunotherapy Guidance in Bacterial Sepsis and COVID-19

2024-10-18T11:44:36+03:00By hiss|Categories: Genetics, Publications|Tags: COVID-19, phenotypes, Sepsis|

Eleni Karakike, Simeon Metallidis, Garyfallia Poulakou, Maria Kosmidou, Nikolaos K. Gatselis, Vasileios Petrakis, Nikoletta Rovina, Eleni Gkeka, Styliani Sympardi, Ilias Papanikolaou, Ioannis Koutsodimitropoulos, Vasiliki Tzavara, Georgios Adamis, Konstantinos Tsiakos, Vasilios Koulouras, Eleni Mouloudi, Eleni Antoniadou, Gykeria Vlachogianni, Souzana Anisoglou, Nikolaos Markou, Antonia Koutsoukou, Periklis Panagopoulos, Haralampos Milionis, George N. Dalekos, Miltiades Kyprianou, Evangelos J.

14 March, 2024

Transitions of blood immune endotypes and improved outcome by anakinra in COVID-19 pneumonia: an analysis of the SAVE-MORE randomized controlled trial

2024-03-14T14:03:07+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Anakinra, clinical trial, COVID-19, Sepsis|

Evdoxia Kyriazopoulou, Yehudit Hasin‐Brumshtein, Uros Midic, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Myrto Astriti, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vasiliki Tzavara, Sofa Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios

13 February, 2024

REACT

2025-07-16T15:24:19+03:00By hiss|Categories: Ongoing, Sepsis and severe infections, Studies|Tags: CAP, clarithromycin, pneumonia, Sepsis, suPAR|

Ongoing study Official Study Title BiomarkeR-guided EArly Clarithromycin Treatment to prevent sepsis progression in community-acquired pneumonia: The REACT Randomized clinical trial Brief Description The primary objective of the REACT RCT is to optimize the clinical benefit from adjunctive clarithromycin treatment shown in the ACCESS trial and to provide evidence for the clinical benefit of