9 March, 2022

Antimicrobial Stewardship Using Biomarkers: Accumulating Evidence for the Critically Ill

2023-02-16T13:21:26+03:00By |Categories: Publications|Tags: , |

Evdoxia Kyriazopoulou, Evangelos J. Giamarellos-Bourboulis Antibiotics 2022 Mar 9;11(3):367 DOI: 10.3390/antibiotics11030367 View article 🡇 Funding This study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: C-reactive protein; COVID-19; ICU; antimicrobial stewardship; biomarker; guided antimicrobial therapy; infection; presepsin; procalcitonin; sepsis

25 February, 2022

Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure

2023-02-16T13:21:55+03:00By |Categories: Publications|Tags: , , |

Evangelos J. Giamarellos-Bourboulis, Garyfallia Poulakou, Aline de Nooijer, Haralampos Milionis, Simeon Metallidis, Michalis Ploumidis, Pinelopi Grigoropoulou, Aggeliki Rapti, Francesco Vladimiro Segala, Evangelos Balis, Efthymia Giannitsioti, Paola Rodari, Ilias Kainis, Zoi Alexiou, Emanuele Focà, Brollo Lucio, Nikoletta Rovina, Laura Scorzolini, Maria Dafni, Sofia Ioannou, Alessandro Tomelleri, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Christina

1 October, 2021

Cytokine production and outcome in MDR versus non-MDR gram-negative bacteraemia and sepsis

2023-02-16T13:23:33+03:00By |Categories: Epidemiology, Publications|Tags: |

Vasileios Karamouzos, Evangelos J. Giamarellos-Bourboulis, Dimitrios Velissaris, Theologia Gkavogianni and Charalambos Gogos Infectious Diseases 2021 Oct;53(10):764-771 DOI: 10.1080/23744235.2021.1925738View the article 🡇 Funding This work was funded by the Hellenic Institute for the study of sepsis. Keywords: Sepsis; cytokines; tumour necrosis factor-a; angiopoietin-2; multidrug resistance; carbapenem resistance

1 July, 2021

ImmunoSep

2024-11-04T09:06:17+03:00By |Categories: Interventional, Ongoing, Sepsis and severe infections, Studies|Tags: |

Ongoing study Official Study Title Personalized Immunotherapy in Sepsis: a multicentre and multinational, double-blind, double-dummy randomized clinical trial Brief Description Previous findings coming from the randomized clinical trial PROVIDE have showed that serum ferritin and expression of HLA-DR on circulating monocytes are reliable diagnostic markers of macrophage activation syndrome and of sepsis-induced immunoparalysis. The

18 June, 2021

A 29-mRNA host response test from blood accurately distinguishes bacterial and viral infections among emergency department patients

2023-02-16T13:25:09+03:00By |Categories: Multicenter studies in Greece, Publications|Tags: , |

Asimina Safarika, James W Wacker, Konstantinos Katsaros, Nicky Solomonidi, George Giannikopoulos, Antigone Kotsaki, Ioannis M Koutelidakis, Sabrina M Coyle, Henry K Cheng, Oliver Liesenfeld, Timothy E Sweeney, Evangelos J. Giamarellos-Bourboulis Intensive Care Medicine Experimental 2021 Jun 18;9(1):31 DOI: 10.1186/s40635-021-00394-8 View article 🡇 Funding The study was funded by Inflammatix.

1 May, 2021

Differential response induced by LPS and MPLA in immunocompetent and septic individuals

2023-02-16T13:25:47+03:00By |Categories: Publications, Sepsis and severe infections|Tags: , |

Chloé Albert Vega, Eleni Karakike, François Bartolo, William Mouton, Elisabeth Cerrato, Karen Brengel-Pesce, Evangelos J. Giamarellos-Bourboulis, François Mallet, Sophie Trouillet-Assant Clinical Immunology 2021 May;226:108714 DOI: 10.1016/j.clim.2021.108714 View article 🡇 Funding This work was supported by Marie Sklodowska-Curie Innovative Training H2020-MSCA-ITN-2015, under the grant agreement No 676129. Keywords: Immune functional

9 March, 2021

Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock

2024-04-01T07:14:49+03:00By |Categories: Pathogenesis, Publications|Tags: |

Rainer König, Amol Kolte, Olaf Ahlers, Marcus Oswald, Veiko Krauss, Daniela Roell, Oliver Sommerfeld, George Dimopoulos, Iraklis Tsangaris, Eleni Antoniadou, Neeraja Jaishankar, Holger Bogatsch, Markus Löffler, Markus Rödel, Marina Garcia-Moreno, Lorena Tuchscherr, Charles L Sprung, Mervyn Singer, Frank Brunkhorst, Michael Oppert, Herwig Gerlach, Ralf A Claus, Sina M Coldewey, Josef Briegel, Evangelos J. Giamarellos-Bourboulis,

1 February, 2021

Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019

2024-03-29T14:07:31+03:00By |Categories: Publications|Tags: , |

Timothy E Sweeney, Oliver Liesenfeld, James Wacker, Yudong D He, David Rawling, Melissa Remmel, Sabrina Coyle, Uros Midic, Antigone Kotsaki, Aggeliki Kanavou, Konstantinos Leventogiannis, Ioanna Kontogeorgou, Evangelos J. Giamarellos-Bourboulis Critical Care Medicine 2021 Feb 1;49(2):e170-e178 DOI: 10.1097/CCM.0000000000004786 Download pdf 🡇 Funding Part of the study was funded by the Hellenic Institute

15 January, 2021

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial

2024-03-29T14:03:16+03:00By |Categories: Publications, Therapeutics|Tags: , , |

Evdoxia Kyriazopoulou, Lydia Liaskou-Antoniou, George Adamis, Antonia Panagaki, Nikolaos Melachroinopoulos, Elina Drakou, Konstantinos Marousis, Georgios Chrysos, Andronikos Spyrou, Nikolaos Alexiou, Styliani Symbardi, Zoi Alexiou, Styliani Lagou, Virginia Kolonia, Theologia Gkavogianni, Miltiades Kyprianou, Ioannis Anagnostopoulos, Garyfallia Poulakou, Malvina Lada, Anna Makina, Efrosyni Roulia, Marina Koupetori, Vasileios Apostolopoulos, Dimitra Petrou, Thomas Nitsotolis, Anastasia Antoniadou, Evangelos J.

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