Sepsis

9 March, 2021

Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock

2024-04-01T07:14:49+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Sepsis|

Rainer König, Amol Kolte, Olaf Ahlers, Marcus Oswald, Veiko Krauss, Daniela Roell, Oliver Sommerfeld, George Dimopoulos, Iraklis Tsangaris, Eleni Antoniadou, Neeraja Jaishankar, Holger Bogatsch, Markus Löffler, Markus Rödel, Marina Garcia-Moreno, Lorena Tuchscherr, Charles L Sprung, Mervyn Singer, Frank Brunkhorst, Michael Oppert, Herwig Gerlach, Ralf A Claus, Sina M Coldewey, Josef Briegel, Evangelos J. Giamarellos-Bourboulis,

1 February, 2021

Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019

2024-03-29T14:07:31+03:00By hiss|Categories: Publications|Tags: COVID-19, Sepsis|

Timothy E Sweeney, Oliver Liesenfeld, James Wacker, Yudong D He, David Rawling, Melissa Remmel, Sabrina Coyle, Uros Midic, Antigone Kotsaki, Aggeliki Kanavou, Konstantinos Leventogiannis, Ioanna Kontogeorgou, Evangelos J. Giamarellos-Bourboulis Critical Care Medicine 2021 Feb 1;49(2):e170-e178 DOI: 10.1097/CCM.0000000000004786 Download pdf 🡇 Funding Part of the study was funded by the Hellenic Institute

15 January, 2021

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial

2024-03-29T14:03:16+03:00By hiss|Categories: Publications, Therapeutics|Tags: clinical trial, procalcitonin, Sepsis|

Evdoxia Kyriazopoulou, Lydia Liaskou-Antoniou, George Adamis, Antonia Panagaki, Nikolaos Melachroinopoulos, Elina Drakou, Konstantinos Marousis, Georgios Chrysos, Andronikos Spyrou, Nikolaos Alexiou, Styliani Symbardi, Zoi Alexiou, Styliani Lagou, Virginia Kolonia, Theologia Gkavogianni, Miltiades Kyprianou, Ioannis Anagnostopoulos, Garyfallia Poulakou, Malvina Lada, Anna Makina, Efrosyni Roulia, Marina Koupetori, Vasileios Apostolopoulos, Dimitra Petrou, Thomas Nitsotolis, Anastasia Antoniadou, Evangelos J.

1 January, 2021

Diabetes on sepsis outcomes in non-ICU patients: A cohort study and review of the literature

2023-02-16T13:36:16+03:00By hiss|Categories: Biomarkers, Publications|Tags: diabetes, Sepsis|

Karolina Akinosoglou, Georgia Kapsokosta, Maria Mouktaroudi, Nikoletta Rovina, Vassileios Kaldis, Aggelos Stefos, Marina Kontogiorgi, Evangelos J. Giamarellos-Bourboulis, Charalambos Gogos, Hellenic Sepsis Study Group Journal of Diabetes and Its Complications 2021 Jan;35(1):107765 DOI: 10.1016/j.jdiacomp.2020.107765View article 🡇 Funding The works were supported by the BMBF within the framework of the “MetaZIK”/ZIK Septomics Jena (03Z2J521),

1 December, 2020

De-escalation of antimicrobial therapy in ICU settings with high prevalence of multidrug-resistant bacteria: a multicentre prospective observational cohort study in patients with sepsis or septic shock

2023-02-16T13:36:45+03:00By hiss|Categories: Multicenter studies in Greece, Publications|Tags: Sepsis, SOFA|

Christina Routsi, Aikaterini Gkoufa, Kostoula Arvaniti, Stelios Kokkoris, Alexandros Tourtoglou, Vassiliki Theodorou, Anna Vemvetsou, Georgios Kassianidis, Athena Amerikanou, Elisabeth Paramythiotou, Efstathia Potamianou, Kyriakos Ntorlis, Angeliki Kanavou, Georgios Nakos, Eleftheria Hassou, Helen Antoniadou, Ilias Karaiskos, Athanasios Prekates, Apostolos Armaganidis, Ioannis Pnevmatikos, Miltiades Kyprianou, Spyros Zakynthinos, Garyfallia Poulakou, Helen Giamarellou Journal of Antimicrobial Chemotherapy 2020 Dec

19 November, 2020

A novel optical biosensor for the early diagnosis of sepsis and severe Covid-19: the PROUD study

2024-03-29T13:55:21+03:00By hiss|Categories: Biomarkers, Publications|Tags: clinical trial, COVID-19, Sepsis|

Sarantia Doulou, Konstantinos Leventogiannis, Maria Tsilika, Matthew Rodencal, Konstantina Katrini, Nikolaos Antonakos, Miltiades Kyprianou, Emmanouil Karofylakis, Athanassios Karageorgos, Panagiotis Koufargyris, Gennaios Christopoulos, George Kassianidis, Kimon Stamatelopoulos, Robert Newberry, Evangelos J. Giamarellos-Bourboulis BMC Infectious Diseases 2020 Nov 19;20(1):860 DOI: 10.1186/s12879-020-05607-1Download pdf 🡇 Funding The study was funded in part by the Hellenic Institute

2 February, 2020

The Prognostic Value of Endotoxemia and Intestinal Barrier Biomarker ZO-1 in Bacteremic Sepsis

2023-02-16T14:30:16+03:00By hiss|Categories: Other Grants, Pathogenesis, Publications|Tags: Sepsis|

Stelios F Assimakopoulos, Karolina Akinosoglou, Anne-Lise de Lastic, Aikaterini Skintzi, Athanasia Mouzaki, Charalambos A Gogos The American Journal of the Medical Sciences 2020 Feb;359(2):100-107 DOI: 10.1016/j.amjms.2019.10.006View article 🡇 Funding The study was funded in part by the Hellenic Institute for the Study of Sepsis (98 / 9-07-2018). Keywords: Bacteremia; Endotoxemia; Gut

29 November, 2019

The early change of SOFA score as a prognostic marker of 28-day sepsis mortality: analysis through a derivation and a validation cohort

2024-03-29T13:19:02+03:00By hiss|Categories: Biomarkers, Publications|Tags: Sepsis, SOFA|

Eleni Karakike, Evdoxia Kyriazopoulou, Iraklis Tsangaris, Christina Routsi, Jean-Louis Vincent, Evangelos J. Giamarellos-Bourboulis Critical Care 2019 Nov 29;23(1):387 DOI: 10.1186/s13054-019-2665-5Download pdf 🡇 Funding The study was funded by unrestricted educational grants provided by the Hellenic Institute for the Study of Sepsis and, by the Horizon 2020 Marie Skłodowska-Curie Grant European Sepsis Academy (grant

1 November, 2019

PROUD-1

2023-01-09T12:14:18+03:00By hiss|Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: COVID-19, Sepsis|

Completed study Official Study Title Pulse PhotoplethysmogAaphy as an early tool for the diagnosis of sepsis thrOUgh a two-stage Development approach Brief Description PROUD-1 is an interventional trial aiming to validate the diagnostic accuracy of a new optical biosensor for the diagnosis of sepsis and for COVID-19. Details Status: Completed Study Type: Interventional

1 September, 2019

Late Peaks of HMGB1 and Sepsis Outcome: Evidence For Synergy With Chronic Inflammatory Disorders

2023-02-16T14:34:19+03:00By hiss|Categories: Publications|Tags: diabetes, Sepsis|

Eleni Karakike, Maria-Evangelia Adami, Malvina Lada, Theologia Gkavogianni, Ioannis M Koutelidakis, Michael Bauer, Evangelos J. Giamarellos-Bourboulis, Iraklis Tsangaris Shock 2019 Sep;52(3):334-339 DOI 10.1097/SHK.0000000000001265 View article 🡇 Funding The study was funded by unrestricted educational grants provided by the Hellenic Institute for the Study of Sepsis, by the Horizon 2020 Marie