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So far hiss has created 187 blog entries.
28 May, 2020

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

2023-02-16T14:28:59+03:00By |Categories: Publications|Tags: |

Mihai G Netea, Evangelos J. Giamarellos-Bourboulis, Jorge Domínguez-Andrés, Nigel Curtis, Reinout van Crevel, Frank L van de Veerdonk, Marc Bonten Cell 2020 May 28;181(5):969-977 DOI 10.1016/j.cell.2020.04.042 View article 🡇 Funding M.G.N. was supported by an ERC advanced grant (833247) and a Spinoza grant of the Netherlands Association for Scientific Research.

1 May, 2020

ACHIEVE

2023-01-09T12:17:31+03:00By |Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: , |

Completed study Official Study Title Anti-inflammatory ClaritHromycin to ImprovE SARS-CoV-2 (COVID-19) infection Early: The ACHIEVE open-label non-randomized clinical trial Brief Description ACHIEVE is an open non-randomized clinical trial aiming to prove that the addition of oral clarithromycin to treatment regimen of COVID-19 is associated with early clinical improvement and attenuation of the high inflammatory

30 April, 2020

Soluble urokinase plasminogen activator receptor (suPAR) as an early predictor of severe respiratory failure in patients with COVID-19 pneumonia

2023-02-16T14:29:21+03:00By |Categories: Biomarkers, Publications|Tags: , |

Nikoletta Rovina, Karolina Akinosoglou, Jesper Eugen-Olsen, Salim Hayek, Jochen Reiser, Evangelos J. Giamarellos-Bourboulis Critical Care 2020 Apr 30;24(1):187 DOI: 10.1186/s13054-020-02897-4View article 🡇 Funding The study was funded by unrestricted educational grants provided by the Hellenic Institute for the Study of Sepsis. Funds were also provided by Rush University Medical Center. Keywords: COVID-19;

1 April, 2020

SAVE

2024-10-18T12:29:07+03:00By |Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: , |

Completed study Official Study Title suPAR-guided Anakinra treatment for Validation of the risk and Early management of severe respiratory failure by COVID-19: the SAVE open-label, non-randomized single-arm trial Brief Description SAVE is an open non-randomized clinical trial aiming to study the early treatment of patients with COVID-19 pneumonia with anakinra guided by the biomarker

1 April, 2020

ESCAPE

2023-01-09T12:13:22+03:00By |Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: , |

Completed study Official Study Title Efficiency in management of organ dysfunction associated with infection by the novel SARS-Cov-2 virus through A PErsonalized immunotherapy approach Brief Description ESCAPE is an open non-randomized clinical trial aiming to the personalized therapy of patients with COVID-19. Using biomarkers, enrolled patients are receiving treatment with intravenous anakinra or intravenous

1 March, 2020

Association of modulation of pro-inflammatory responses by dectin-2 with preterm delivery: An experimental model

2023-02-16T14:29:56+03:00By |Categories: Publications|Tags: |

Aspasia Liassidou, Georgios Renieris, Dionysia-Irene Droggiti, Theologia Gkavogianni, Christakis Liassides, Labros Sabracos, Evangelos J. Giamarellos-Bourboulis, Charalampos S Siristatidis American Journal of Reproductive Immunology 2020 Mar;83(3):e13216 DOI 10.1111/aji.13216 View article 🡇 Keywords: dectin-2; infection; lipopolysaccharide; miscarriage; preterm delivery

2 February, 2020

The Prognostic Value of Endotoxemia and Intestinal Barrier Biomarker ZO-1 in Bacteremic Sepsis

2023-02-16T14:30:16+03:00By |Categories: Other Grants, Pathogenesis, Publications|Tags: |

Stelios F Assimakopoulos, Karolina Akinosoglou, Anne-Lise de Lastic, Aikaterini Skintzi, Athanasia Mouzaki, Charalambos A Gogos The American Journal of the Medical Sciences 2020 Feb;359(2):100-107 DOI: 10.1016/j.amjms.2019.10.006View article 🡇 Funding The study was funded in part by the Hellenic Institute for the Study of Sepsis (98 / 9-07-2018). Keywords: Bacteremia; Endotoxemia; Gut

28 January, 2020

Staphylococcus Aureus Osteomyelitis as an Inducer of Tolerance to Escherichia Coli Pyelonephritis: an Experimental Study

2023-02-16T14:30:39+03:00By |Categories: Publications|Tags: |

Stavros Goumenos, Olga Savvidou, George Renieris, Theologia Gkavogianni, Panayiotis J Papagelopoulos, Evangelos J. Giamarellos-Bourboulis Scientific Reports 2020 Jan 28;10(1):1345 DOI 10.1038/s41598-020-58420-w View article 🡇 FundingE.J. Giamarellos-Bourboulis has received honoraria (paid to the University of Athens) from AbbVie USA, Abbott CH, Biotest Germany, Brahms GmbH, InflaRx GmbH, MSD Greece and XBiotech Inc. He has

1 January, 2020

Survival benefit associated with clarithromycin in severe community-acquired pneumonia: A matched comparator study

2023-02-16T14:31:00+03:00By |Categories: Publications, Therapeutics|Tags: , , |

Evdoxia Kyriazopoulou, Dimitrios Sinapidis, Stamatios Halvatzis, Dimitrios Velissaris, Nikolaos Alexiou, Vasilios Kosmas, Maria-Evangelia Adami, Miltiades Kyprianou, Aikaterini Kyprianou, Aggelos Stefos, Malvina Lada, Pantelis Koutoukas, Maria Pavlaki, Anna Kyriakoudi, Anna Makina, Charalambos Gogos, Michael S Niederman, Evangelos J. Giamarellos-Bourboulis International Journal of Antimicrobial Agents 2020 Jan;55(1):105836 DOI: 10.1016/j.ijantimicag.2019.10.017View article 🡇 Funding The works were

1 December, 2019

Microbiology of acute bacterial skin and skin-structure infections in Greece: A proposed clinical prediction score for the causative pathogen

2023-02-16T14:31:22+03:00By |Categories: Multicenter studies in Greece, Pathogenesis, Publications|Tags: , |

Christos Nodaras, Antigoni Kotsaki, Nikolaos Tziolos, Theano Kontopoulou, Karolina Akinosoglou, Maria Chrisanthakopoulou, Eleftheria Kranidioti, Ioannis Kritselis, Nikolaos Voloudakis, Vassilios Vittoros, Agathoniki Gogkou, Ilias Fillas, Konstantinos G Toutouzas, Magdalini Bristianou, Dimosthenis Tsoutsos, Eirini Christaki, George Adamis, Katerina Kaziani, Christos Tsironis, Malvina Lada, Evangelos Kokkinakis, Styliani Sympardi, Ioannis M Koutelidakis, Achilleas Karkamanis, Aikaterini Pantazi, Cihat Bayram,

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