Pathogenesis

14 March, 2024

Transitions of blood immune endotypes and improved outcome by anakinra in COVID-19 pneumonia: an analysis of the SAVE-MORE randomized controlled trial

2024-03-14T14:03:07+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Anakinra, clinical trial, COVID-19, Sepsis|

Evdoxia Kyriazopoulou, Yehudit Hasin‐Brumshtein, Uros Midic, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Myrto Astriti, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vasiliki Tzavara, Sofa Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios

19 December, 2022

Interferon gamma-induced protein 10 (IP-10) for the early prognosis of the risk for severe respiratory failure and death in COVID-19 pneumonia

2024-04-02T18:36:36+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Anakinra, clinical trial, COVID-19|

Charilaos Samaras, Evdoxia Kyriazopoulou, Garyfallia Poulakou, Eran Reiner, Maria Kosmidou, Ioanna Karanika, Vasileios Petrakis, George Adamis, Nikolaos K. Gatselis, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, George Chrysos, Giulia Bertoli, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Evangelos Kostis, Lorenzo Dagna, Sofia Koukidou, Glykeria Tzatzagou,

9 March, 2021

Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock

2024-04-01T07:14:49+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Sepsis|

Rainer König, Amol Kolte, Olaf Ahlers, Marcus Oswald, Veiko Krauss, Daniela Roell, Oliver Sommerfeld, George Dimopoulos, Iraklis Tsangaris, Eleni Antoniadou, Neeraja Jaishankar, Holger Bogatsch, Markus Löffler, Markus Rödel, Marina Garcia-Moreno, Lorena Tuchscherr, Charles L Sprung, Mervyn Singer, Frank Brunkhorst, Michael Oppert, Herwig Gerlach, Ralf A Claus, Sina M Coldewey, Josef Briegel, Evangelos J. Giamarellos-Bourboulis,

1 November, 2020

Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Coronavirus

2024-03-29T13:45:05+03:00By hiss|Categories: Pathogenesis, Publications|Tags: COVID-19|

Georgios Renieris, Konstantina Katrini, Christina Damoulari, Karolina Akinosoglou, Christos Psarrakis, Magdalini Kyriakopoulou, George Dimopoulos, Malvina Lada, Panagiotis Koufargyris, Evangelos J. Giamarellos-Bourboulis Shock 2020 Nov;54(5):633-637 DOI: 10.1097/SHK.0000000000001562Download pdf 🡇 Funding GR is funded from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement grant European Sepsis Academy (agreement

8 July, 2020

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

2024-03-29T13:31:59+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Anakinra, COVID-19|

George Dimopoulos, Quirijn de Mast, Nikolaos Markou, Maria Theodorakopoulou, Apostolos Komnos, Maria Mouktaroudi, Mihai G Netea, Themistoklis Spyridopoulos, Rebecca J Verheggen, Jacobien Hoogerwerf, Alexandra Lachana, Frank L van de Veerdonk, Evangelos J. Giamarellos-Bourboulis Cell Host & Microbe 2020 Jul 8;28(1):117-123.e1 DOI 10.1016/j.chom.2020.05.007Download pdf 🡇 Funding The study was funded in part by the

1 June, 2020

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

2024-04-01T07:03:28+03:00By hiss|Categories: Pathogenesis, Publications|Tags: COVID-19|

Evangelos J. Giamarellos-Bourboulis, Mihai G Netea, Nikoletta Rovina, Karolina Akinosoglou, Anastasia Antoniadou, Nikolaos Antonakos, Georgia Damoraki, Theologia Gkavogianni, Maria-Evangelia Adami, Paraskevi Katsaounou, Maria Ntaganou, Magdalini Kyriakopoulou, George Dimopoulos, Ioannis Koutsodimitropoulos, Dimitrios Velissaris, Panagiotis Koufargyris, Athanassios Karageorgos, Konstantina Katrini, Vasileios Lekakis, Mihaela Lupse, Antigone Kotsaki, George Renieris, Danai Theodoulou, Vassiliki Panou, Evangelia Koukaki, Nikolaos Koulouris,

2 February, 2020

The Prognostic Value of Endotoxemia and Intestinal Barrier Biomarker ZO-1 in Bacteremic Sepsis

2023-02-16T14:30:16+03:00By hiss|Categories: Other Grants, Pathogenesis, Publications|Tags: Sepsis|

Stelios F Assimakopoulos, Karolina Akinosoglou, Anne-Lise de Lastic, Aikaterini Skintzi, Athanasia Mouzaki, Charalambos A Gogos The American Journal of the Medical Sciences 2020 Feb;359(2):100-107 DOI: 10.1016/j.amjms.2019.10.006View article 🡇 Funding The study was funded in part by the Hellenic Institute for the Study of Sepsis (98 / 9-07-2018). Keywords: Bacteremia; Endotoxemia; Gut

1 December, 2019

Microbiology of acute bacterial skin and skin-structure infections in Greece: A proposed clinical prediction score for the causative pathogen

2023-02-16T14:31:22+03:00By hiss|Categories: Multicenter studies in Greece, Pathogenesis, Publications|Tags: clinical trial, skin infections|

Christos Nodaras, Antigoni Kotsaki, Nikolaos Tziolos, Theano Kontopoulou, Karolina Akinosoglou, Maria Chrisanthakopoulou, Eleftheria Kranidioti, Ioannis Kritselis, Nikolaos Voloudakis, Vassilios Vittoros, Agathoniki Gogkou, Ilias Fillas, Konstantinos G Toutouzas, Magdalini Bristianou, Dimosthenis Tsoutsos, Eirini Christaki, George Adamis, Katerina Kaziani, Christos Tsironis, Malvina Lada, Evangelos Kokkinakis, Styliani Sympardi, Ioannis M Koutelidakis, Achilleas Karkamanis, Aikaterini Pantazi, Cihat Bayram,

29 May, 2018

Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection

2024-03-28T17:18:57+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Sepsis|

Dimitrios Sinapidis, Vassileios Kosmas, Vasileios Vittoros, Ioannis M. Koutelidakis, Aikaterini Pantazi, Aggelos Stefos, Konstantinos E. Katsaros, Karolina Akinosoglou, Magdalini Bristianou, Konstantinos Toutouzas, Michael Chrisofos and Evangelos J. Giamarellos-Bourboulis BMC Infectious Diseases, May 2018 DOI 10.1186/s12879-018-3156-zDownload pdf 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis.

1 December, 2017

Platelet reactivity in sepsis syndrome: results from the PRESS study

2023-02-16T15:08:41+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Sepsis|

Karolina Akinosoglou, Spyridoula Theodoraki, Ioanna Xanthopoulou, Angelos Perperis, Theologia Gkavogianni, Aikaterini Pistiki, Evangelos J Giamarellos-Bourboulis, Charalambos A Gogos European Journal of Clinical Microbiology & Infectious Diseases 2017 Dec;36(12):2503-2512 DOI: 10.1007/s10096-017-3093-6View the article 🡇 Funding This work was funded by the Hellenic Institute for the Study of Sepsis. Keywords: Organ dysfunction; P2Y12 platelet