Publications

23 October, 2025

Hydrogen sulfide to modulate Glycated hemoglobin and gut microbiome in type 2 diabetes mellitus

2025-10-23T17:04:33+03:00By hiss|Categories: Biomarkers, Publications|Tags: diabetes, microbiome|

Sokratis Katopodis, Emmanouil Stylianakis, Panagiotis Koufargyris, Maria Mouktaroudi, Konstantina Dakou, Spyros Foutadakis, Georgia Damoraki, Konstantinos Triantafyllou, Evangelos J. Giamarellos-Bourboulis, Erifili Hatziagelaki Metabolism Open, Volume 28, 2025, 100405, ISSN 2589-9368 DOI: 10.1016/j.ebiom.2016.03.006Download pdf 🡇 Funding This study was funded by the Hellenic Institute for the Study of Sepsis (HISS). Keywords: Hydrogen sulfide;

1 September, 2025

An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis

2025-09-06T11:28:43+03:00By hiss|Categories: Biomarkers, Publications|Tags: diagnosis, Sepsis|

Pinzauti David, Biazzo Manuele, Podrini Christine, Alevizou Antonia, Safarika Asimina, Damoraki Georgia, Koufargyris Panagiotis, Tasouli Elisavet, Skopelitis Ilias, Poulakou Garyfallia, Sympardi Styliani and Evangelos J. Giamarellos-Bourboulis Front. Cell. Infect. Microbiol. 15:1656171 DOI: 10.3389/fcimb.2025.1656171Download pdf 🡇 Funding The author(s) declare financial support was received for the research and/or publication of this article. The

9 August, 2025

Biomarkers to guide sepsis management

2025-08-22T19:16:30+03:00By hiss|Categories: Biomarkers, Publications|Tags: Sepsis|

Vasiliki Bourika, Evangelia-Areti Rekoumi and Evangelos J. Giamarellos-Bourboulis Ann Intensive Care. 2025 Jul 21;15(1):103 DOI: 10.1186/s13613-025-01524-1Download pdf 🡇 Funding No funding was provided for this manuscript. Keywords: Sepsis, Biomarkers, Guidance, Antibiotics, Fluids, Vasopressors

1 July, 2025

29-mRNA host response signatures for classifcation of bacterial infection, viral infection and disease progression in COVID-19 pneumonia: a post hoc analysis of the SAVE-MORE randomized clinical trial

2025-07-01T22:02:55+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19, infection, pneumonia, Sepsis|

Evdoxia Kyriazopoulou, Antigone Kotsaki, Asimina Safarika, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Georgios Adamis, Archontoula Fragkou, Aggeliki Rapti, Pierluigi Del Vecchio, Ioannis Kalomenidis, Danae Kitzoglou, Andrea Angheben, Ilias Kainis, Konstantina Iliopoulou, Francesco Saverio Serino, Petros Bakakos, Vassiliki Tzavara, Sofa Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassett, Vasileios Kotsis, George Tsoukalas,

12 May, 2025

Procalcitonin-guided early cessation of antibiotics prevents gut inflammation and preserves gut microbiome: Data from the PROGRESS controlled trial

2025-05-12T15:05:05+03:00By hiss|Categories: Biomarkers, Publications|Tags: microbiome, procalcitonin, Sepsis|

Evdoxia Kyriazopoulou, Emmanouil Stylianakis, Georgia Damoraki, Panagiotis Koufargyris, Ioannis Kollias, Konstantina Katrini, Elina Drakou, Konstantinos Marousis, Andronikos Spyrou, Styliani Symbardi, Nikolaos Alexiou, Zoi Alexiou, Malvina Lada, Garyfallia Poulakou, Georgios Chrysos, George Adamis, Evangelos J. Giamarellos-Bourboulis Int J Antimicrob Agents. 2025 Apr 9:107507 DOI: 10.1016/j.ijantimicag.2025.107507 View article 🡆 FundingHellenic Institute for the Study of Sepsis

9 April, 2025

The EMBRACE trial at the 44th International Symposium of Intensive Care and Emergency Medicine

2025-04-09T09:31:05+03:00By hiss|Categories: Publications, Sepsis and severe infections|Tags: emapalumab, Interferon-gamma, poster, Studies on Sepsis and severe infections|

Ourania Konstantinidou, Elisavet Olntasi, Helena Florou, Souzana Anisoglou, Eleni Antoniadou, George Dimopoulos, Eleni Gkeka, Aikaterini Ioakeimidou, Vassileios Karamouzos, Efmorphia Kondili, Zafeiria Mastora, Eleni Mouloudi, Pavlos Myrianthefs, Maria Ntaganou, Elissavet Paramythiotou, Vassilis Papaioannou, Maria Patrani, Nikoletta Rovina, Glykeria Vlachogianni, Armin J. Reininger, Evangelos J. Giamarellos-Bourboulis 44th International Symposium of Intensive Care and Emergency

26 February, 2025

Recent advances of precision immunotherapy in sepsis

2025-03-10T10:51:58+03:00By hiss|Categories: Publications|Tags: Anakinra, Interferon-gamma, Sepsis|

Antonios Arapis, Dimitrios Panagiotopoulos, Evangelos J. Giamarellos-Bourboulis Burns & Trauma, 2025, 13, tkaf001 DOI: 10.1093/burnst/tkaf001Download pdf 🡇 Keywords: Precision immunotherapy; Sepsis; Anakinra; Nangibotide; Nivolumab; Interferon-gamma; Growth factors; Adrecizumab

10 January, 2025

Clarithromycin for improved clinical outcomes in community-acquired pneumonia: A subgroup analysis of the ACCESS trial

2025-01-10T13:53:31+03:00By hiss|Categories: Publications, Therapeutics|Tags: clarithromycin, pneumonia|

Karolina Akinosoglou, Konstantinos Leventogiannis, Elisavet Tasouli, Nikolaos Kakavoulis, Georgios Niotis, Sarantia Doulou, Lamprini Skorda, Konstantina Iliopoulou, Anna Papailiou, Paraskevi Katsaounou, Vassiliki Rapti, George Chrysos, Theodoros Seferlis, Styliani Gerakari, Konstantina Dakou, Ilias C. Papanikolaou, Haralampos Milionis, Samantha Kewitz, Sara Georgiadou, Theano Kontopoulou, Vasiliki Tzavara, Antonio Torres, Michael S. Niederman, Evangelos J. Giamarellos-Bourboulis Int

10 January, 2025

Anakinra Efficacy in COVID-19 Pneumonia Guided by Soluble Urokinase Plasminogen Activator Receptor: Association With the Inflammatory Burden of the Host

2025-01-10T13:53:22+03:00By hiss|Categories: Biomarkers, Publications|Tags: Anakinra, COVID-19, mortality, suPAR|

Evdoxia Kyriazopoulou, Karolina Akinosoglou, Eleni Florou, Elli Kouriannidi, Artemis Bogosian, Olga Tsachouridou, Konstantinos N. Syrigos, Nikolaos Gatselis, Haralampos Milionis, Ilias C. Papanikolaou, Styliani Sympardi, Maria Dafni, Antonia Alevizou, Alexia-Vasiliki Amvrazi, Errika Alexandrou, Kyprianos Archontoulis, Katerina Argyraki, Zoi Alexiou, Yakinthi Georgiou, Dimitra Gkogka, Foteini Kyrailidi, Vassiliki Kalyva, Triantafilli Nikolopoulou, Sofia Ioannou, Petros Bakakos, Georgia Karathanassiou,

25 October, 2024

Interferon-gamma driven elevation of CXCL9: a new sepsis endotype independently associated with mortality

2024-10-25T09:53:56+03:00By hiss|Categories: Biomarkers, Publications|Tags: Interferon-gamma, mortality, Sepsis|

Evangelos J. Giamarellos-Bourboulis, Massimo Antonelli, Frank Bloos, Ioanna Kotsamidi, Christos Psarrakis, Konstantina Dakou, Daniel Thomas-Rüddel, Luca Montini, Josef Briegel, Georgia Damoraki, Panagiotis Koufargyris, Souzana Anisoglou, Eleni Antoniadou, Glykeria Vlachogianni, Christos Tsiantas, Matteo Masullo, Aikaterini Ioakeimidou, Eumorfia Kondili, Maria Ntaganou, Eleni Gkeka, Vassileios Papaioannou, Effie Polyzogopoulou, Armin J Reininger, Gennaro De Pascale, Michael Kiehntopf, Eleni