Publications

2 January, 2026

Efficacy of anakinra in reducing progression to organ dysfunction in patients with pneumonia (INSPIRE): a randomised, double-blind, placebo-controlled phase IIa trial

2026-01-02T12:36:23+03:00By hiss|Categories: Biomarkers, Publications, Therapeutics|Tags: Anakinra, mortality, pneumonia, presepsin|

Georgios Tavoulareas, Olga Kontakou-Zoniou, Nikolaos Antonakos, Elisavet Tasouli, George Adamis, Nikolaos Kakavoulis, Evangelos Michelakis, Ilias Skopelitis, Konstantina Dakou, Christos Psarrakis, Panagiotis Koufargyris, Myrto Astriti, Styliani Sympardi, and Evangelos J. Giamarellos-Bourboulis The Lancet Regional Health - Europe 2026;62: 101573 DOI: 10.1016/j.lanepe.2025.101573Download pdf 🡇 Funding Hellenic Institute for the Study of Sepsis; PHC Europe BV;

14 December, 2025

Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial

2025-12-14T19:48:06+03:00By hiss|Categories: Publications, Sepsis and severe infections, Therapeutics|Tags: Sepsis, Studies on Sepsis and severe infections|

Evangelos J. Giamarellos-Bourboulis, Antigone Kotsaki, Ioanna Kotsamidi, Aikaterini Efthymiou, Vasiliki Koutsoukou, Johannes Ehler, Alexandra Paridou, Frantzeska Frantzeskaki, Marcella C. A. Müller, Peter Pickkers, Sylvain Meylan, Ioannis Nikolopoulos, Mihaela Lupse, Alexandra Gavala, Glykeria Vlachogianni, Nicky Solomonidi, Antonia Alevizou, Eumorfia Kondili, Eleni Antoniadou, Maria Nakou, Nikolaos Markou, Erifili Hatziagelaki, Athanassios Prekates, Apostolos Komnos, Lieke Bakkerus, Marleen A.

23 October, 2025

Hydrogen sulfide to modulate Glycated hemoglobin and gut microbiome in type 2 diabetes mellitus

2025-10-23T17:04:33+03:00By hiss|Categories: Biomarkers, Publications|Tags: diabetes, microbiome|

Sokratis Katopodis, Emmanouil Stylianakis, Panagiotis Koufargyris, Maria Mouktaroudi, Konstantina Dakou, Spyros Foutadakis, Georgia Damoraki, Konstantinos Triantafyllou, Evangelos J. Giamarellos-Bourboulis, Erifili Hatziagelaki Metabolism Open, Volume 28, 2025, 100405, ISSN 2589-9368 DOI: 10.1016/j.ebiom.2016.03.006Download pdf 🡇 Funding This study was funded by the Hellenic Institute for the Study of Sepsis (HISS). Keywords: Hydrogen sulfide;

1 September, 2025

An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis

2025-09-06T11:28:43+03:00By hiss|Categories: Biomarkers, Publications|Tags: diagnosis, Sepsis|

Pinzauti David, Biazzo Manuele, Podrini Christine, Alevizou Antonia, Safarika Asimina, Damoraki Georgia, Koufargyris Panagiotis, Tasouli Elisavet, Skopelitis Ilias, Poulakou Garyfallia, Sympardi Styliani and Evangelos J. Giamarellos-Bourboulis Front. Cell. Infect. Microbiol. 15:1656171 DOI: 10.3389/fcimb.2025.1656171Download pdf 🡇 Funding The author(s) declare financial support was received for the research and/or publication of this article. The

9 August, 2025

Biomarkers to guide sepsis management

2025-08-22T19:16:30+03:00By hiss|Categories: Biomarkers, Publications|Tags: Sepsis|

Vasiliki Bourika, Evangelia-Areti Rekoumi and Evangelos J. Giamarellos-Bourboulis Ann Intensive Care. 2025 Jul 21;15(1):103 DOI: 10.1186/s13613-025-01524-1Download pdf 🡇 Funding No funding was provided for this manuscript. Keywords: Sepsis, Biomarkers, Guidance, Antibiotics, Fluids, Vasopressors

1 July, 2025

29-mRNA host response signatures for classifcation of bacterial infection, viral infection and disease progression in COVID-19 pneumonia: a post hoc analysis of the SAVE-MORE randomized clinical trial

2025-07-01T22:02:55+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19, infection, pneumonia, Sepsis|

Evdoxia Kyriazopoulou, Antigone Kotsaki, Asimina Safarika, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Georgios Adamis, Archontoula Fragkou, Aggeliki Rapti, Pierluigi Del Vecchio, Ioannis Kalomenidis, Danae Kitzoglou, Andrea Angheben, Ilias Kainis, Konstantina Iliopoulou, Francesco Saverio Serino, Petros Bakakos, Vassiliki Tzavara, Sofa Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassett, Vasileios Kotsis, George Tsoukalas,

12 May, 2025

Procalcitonin-guided early cessation of antibiotics prevents gut inflammation and preserves gut microbiome: Data from the PROGRESS controlled trial

2025-05-12T15:05:05+03:00By hiss|Categories: Biomarkers, Publications|Tags: microbiome, procalcitonin, Sepsis|

Evdoxia Kyriazopoulou, Emmanouil Stylianakis, Georgia Damoraki, Panagiotis Koufargyris, Ioannis Kollias, Konstantina Katrini, Elina Drakou, Konstantinos Marousis, Andronikos Spyrou, Styliani Symbardi, Nikolaos Alexiou, Zoi Alexiou, Malvina Lada, Garyfallia Poulakou, Georgios Chrysos, George Adamis, Evangelos J. Giamarellos-Bourboulis Int J Antimicrob Agents. 2025 Apr 9:107507 DOI: 10.1016/j.ijantimicag.2025.107507 View article 🡆 FundingHellenic Institute for the Study of Sepsis

9 April, 2025

The EMBRACE trial at the 44th International Symposium of Intensive Care and Emergency Medicine

2025-04-09T09:31:05+03:00By hiss|Categories: Publications, Sepsis and severe infections|Tags: emapalumab, Interferon-gamma, poster, Studies on Sepsis and severe infections|

Ourania Konstantinidou, Elisavet Olntasi, Helena Florou, Souzana Anisoglou, Eleni Antoniadou, George Dimopoulos, Eleni Gkeka, Aikaterini Ioakeimidou, Vassileios Karamouzos, Efmorphia Kondili, Zafeiria Mastora, Eleni Mouloudi, Pavlos Myrianthefs, Maria Ntaganou, Elissavet Paramythiotou, Vassilis Papaioannou, Maria Patrani, Nikoletta Rovina, Glykeria Vlachogianni, Armin J. Reininger, Evangelos J. Giamarellos-Bourboulis 44th International Symposium of Intensive Care and Emergency

26 February, 2025

Recent advances of precision immunotherapy in sepsis

2025-03-10T10:51:58+03:00By hiss|Categories: Publications|Tags: Anakinra, Interferon-gamma, Sepsis|

Antonios Arapis, Dimitrios Panagiotopoulos, Evangelos J. Giamarellos-Bourboulis Burns & Trauma, 2025, 13, tkaf001 DOI: 10.1093/burnst/tkaf001Download pdf 🡇 Keywords: Precision immunotherapy; Sepsis; Anakinra; Nangibotide; Nivolumab; Interferon-gamma; Growth factors; Adrecizumab

10 January, 2025

Clarithromycin for improved clinical outcomes in community-acquired pneumonia: A subgroup analysis of the ACCESS trial

2025-01-10T13:53:31+03:00By hiss|Categories: Publications, Therapeutics|Tags: clarithromycin, pneumonia|

Karolina Akinosoglou, Konstantinos Leventogiannis, Elisavet Tasouli, Nikolaos Kakavoulis, Georgios Niotis, Sarantia Doulou, Lamprini Skorda, Konstantina Iliopoulou, Anna Papailiou, Paraskevi Katsaounou, Vassiliki Rapti, George Chrysos, Theodoros Seferlis, Styliani Gerakari, Konstantina Dakou, Ilias C. Papanikolaou, Haralampos Milionis, Samantha Kewitz, Sara Georgiadou, Theano Kontopoulou, Vasiliki Tzavara, Antonio Torres, Michael S. Niederman, Evangelos J. Giamarellos-Bourboulis Int