Publications

7 November, 2022

A randomized clinical trial of lipid metabolism modulation with fenofibrate for acute coronavirus disease 2019

2023-02-16T12:33:18+03:00By hiss|Categories: Publications|Tags: clinical trial, COVID-19, metabolism|

Julio A Chirinos, Patricio Lopez-Jaramillo, Evangelos J. Giamarellos-Bourboulis, Gonzalo H Dávila-Del-Carpio, Abdul Rahman Bizri, Jaime F Andrade-Villanueva, Oday Salman, Carlos Cure-Cure, Nelson R Rosado-Santander, Mario P Cornejo Giraldo, Luz A González-Hernández, Rima Moghnieh, Rapti Angeliki, María E Cruz Saldarriaga, Marcos Pariona, Carola Medina, Ioannis Dimitroulis, Charalambos Vlachopoulos, Corina Gutierrez, Juan E Rodriguez-Mori, Edgar Gomez-Laiton,

1 November, 2022

Toward personalized immunotherapy in sepsis: The PROVIDE randomized clinical trial

2024-04-02T18:31:09+03:00By hiss|Categories: Multicenter studies in Greece, Publications|Tags: Anakinra, clinical trial, Sepsis|

Konstantinos Leventogiannis, Evdoxia Kyriazopoulou, Nikolaos Antonakos, Antigone Kotsaki, Iraklis Tsangaris, Dimitra Markopoulou, Inge Grondman, Nikoleta Rovina, Vassiliki Theodorou, Eleni Antoniadou, Ioannis Koutsodimitropoulos, George Dalekos, Glykeria Vlachogianni, Karolina Akinosoglou, Vassileios Koulouras, Apostolos Komnos, Theano Kontopoulou, Athanassios Prekates, Antonia Koutsoukou, Jos WM van der Meer, George Dimopoulos, Miltiades Kyprianou, Mihai G Netea, Evangelos J. Giamarellos-Bourboulis

1 September, 2022

A 29-MRNA HOST RESPONSE WHOLE-BLOOD SIGNATURE IMPROVES PREDICTION OF 28-DAY MORTALITY AND 7-DAY INTENSIVE CARE UNIT CARE IN ADULTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH SUSPECTED ACUTE INFECTION AND/OR SEPSIS

2023-02-16T12:35:03+03:00By hiss|Categories: Publications|Tags: Sepsis|

Antigone Kotsaki, James W Wacker, Asimina Safarika, Nicky Solomonidi, Konstantinos Katsaros, George Giannikopoulos, Ioannis M Koutelidakis, Catherine A Hogan, Florian Uhle, Oliver Liesenfeld, Timothy E Sweeney, Evangelos J. Giamarellos-Bourboulis Shock 2022 Sep 1;58(3):224-230 DOI: 10.1097/SHK.0000000000001970 View article 🡇 Funding This study was supported in part by Inflammatix Inc. and

5 July, 2022

ACTIVATE-2: A Double-Blind Randomized Trial of BCG Vaccination Against COVID-19 in Individuals at Risk

2024-04-02T18:24:39+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: BCG, clinical trial, COVID-19, vaccination|

Maria Tsilika, Esther Taks, Konstantinos Dolianitis, Antigone Kotsaki, Konstantinos Leventogiannis, Christina Damoulari, Maria Kostoula, Maria Paneta, Georgios Adamis, Ilias Papanikolaou, Kimon Stamatelopoulos, Amalia Bolanou, Konstantinos Katsaros, Christina Delavinia, Ioannis Perdios, Aggeliki Pandi, Konstantinos Tsiakos, Nektarios Proios, Emmanouela Kalogianni, Ioannis Delis, Efstathios Skliros, Karolina Akinosoglou, Aggeliki Perdikouli, Garyfallia Poulakou, Haralampos Milionis, Eva Athanassopoulou, Eleftheria Kalpaki,

4 July, 2022

MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity

2023-02-16T12:36:27+03:00By hiss|Categories: Other Grants, Publications|Tags: metabolism|

Antonia Katsouda, Dimitrios Valakos, Vasilios S Dionellis, Sofia-Iris Bibli, Ioannis Akoumianakis, Sevasti Karaliota, Karim Zuhra, Ingrid Fleming, Noriyuki Nagahara, Sophia Havaki, Vassilis G Gorgoulis, Dimitris Thanos, Charalambos Antoniades, Csaba Szabo, Andreas Papapetropoulos Journal of Experimental Medicine 2022 Jul 4;219(7):e20211894 DOI: 10.1084/jem.20211894View article 🡇 Funding This research has been cofinanced by the

18 June, 2022

Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial

2023-02-16T12:38:06+03:00By hiss|Categories: Publications|Tags: clarithromycin, clinical trial, Sepsis|

Eleni Karakike, Brendon P Scicluna, Maria Roumpoutsou, Ioannis Mitrou, Niki Karampela, Athanasios Karageorgos, Konstantinos Psaroulis, Eleni Massa, Achillefs Pitsoulis, Panagiotis Chaloulis, Evanthia Pappa, Irene T Schrijver, Frantzeska Frantzeskaki, Malvina Lada, Nicolas Dauby, David De Bels, Ioannis Floros, Souzana Anisoglou, Eleni Antoniadou, Maria Patrani, Glykeria Vlachogianni, Eleni Mouloudi, Anastasia Antoniadou, David Grimaldi, Thierry Roger, W

1 May, 2022

ESCAPE: An Open-Label Trial of Personalized Immunotherapy in Critically ill COVID-19 Patients

2024-04-02T18:18:52+03:00By hiss|Categories: Publications, Therapeutics|Tags: clinical trial, COVID-19, Tocilizumab|

Eleni Karakike, George N Dalekos, Ioannis Koutsodimitropoulos, Maria Saridaki, Chryssa Pourzitaki, Georgios Papathanakos, Antigone Kotsaki, Stamatios Chalvatzis, Vasiliki Dimakopoulou, Nikolaos Vechlidis, Elisabeth Paramythiotou, Christina Avgoustou, Aikaterini Ioakeimidou, Elli Kouriannidi, Apostolos Komnos, Evangelia Neou, Nikoletta Rovina, Eleni Stefanatou, Haralampos Milionis, George Nikolaidis, Antonia Koutsoukou, Georgia Damoraki, George Dimopoulos, Vassileios Zoumpos, Jesper Eugen-Olsen, Karolina Akinosoglou, Nikolaos

28 April, 2022

Calprotectin and Imbalances between Acute-Phase Mediators Are Associated with Critical Illness in COVID-19

2023-02-16T12:38:10+03:00By hiss|Categories: Publications|Tags: COVID-19|

Georgios Kassianidis, Athanasios Siampanos, Garyphalia Poulakou, George Adamis, Aggeliki Rapti, Haralampos Milionis, George N Dalekos, Vasileios Petrakis, Styliani Sympardi, Symeon Metallidis, Zoi Alexiou, Theologia Gkavogianni, Evangelos J. Giamarellos-Bourboulis, Theoharis C Theoharides International Journal of Molecular Sciences 2022 Apr 28;23(9):4894 DOI: 10.3390/ijms23094894 View article 🡇 Funding All reagent kits were provided

9 March, 2022

Antimicrobial Stewardship Using Biomarkers: Accumulating Evidence for the Critically Ill

2023-02-16T13:21:26+03:00By hiss|Categories: Publications|Tags: COVID-19, Sepsis|

Evdoxia Kyriazopoulou, Evangelos J. Giamarellos-Bourboulis Antibiotics 2022 Mar 9;11(3):367 DOI: 10.3390/antibiotics11030367 View article 🡇 Funding This study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: C-reactive protein; COVID-19; ICU; antimicrobial stewardship; biomarker; guided antimicrobial therapy; infection; presepsin; procalcitonin; sepsis

25 February, 2022

Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure

2023-02-16T13:21:55+03:00By hiss|Categories: Publications|Tags: COVID-19, Sepsis, suPAR|

Evangelos J. Giamarellos-Bourboulis, Garyfallia Poulakou, Aline de Nooijer, Haralampos Milionis, Simeon Metallidis, Michalis Ploumidis, Pinelopi Grigoropoulou, Aggeliki Rapti, Francesco Vladimiro Segala, Evangelos Balis, Efthymia Giannitsioti, Paola Rodari, Ilias Kainis, Zoi Alexiou, Emanuele Focà, Brollo Lucio, Nikoletta Rovina, Laura Scorzolini, Maria Dafni, Sofia Ioannou, Alessandro Tomelleri, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Christina