Studies
Completed study Official Study Title Pulse PhotoplethysmogAaphy as an early tool for the diagnosis of sepsis thrOUgh a two-stage Development approach Brief Description PROUD-1 is an interventional trial aiming to validate the diagnostic accuracy of a new optical biosensor for the diagnosis of sepsis and for COVID-19. Details Status: Completed Study Type: Interventional
Completed study Official Study Title Heparin AnticoaguLation to improve Outcomes in septic shock: The HALO international phase II RCT Brief Description HALO-HCA2017 is a randomized clinical trial aiming to study if heparin, a widely available, inexpensive anticoagulant, may improve clinical outcomes in patients with septic shock. Details Status: Completed Study Type: Interventional (Clinical
Completed study Official Study Title A double-blind, randomised, placebo-controlled clinical trial of the safety and efficacy of MABp1, a- first-in-class true human antibody targeting interleukin-1alpha, in patients with hidradenitis suppurativa not eligible for adalimumab Brief Description LIGHT is a double-blind randomized study aiming to the comparison of the efficacy of MABp1 (Bermekimab), a fully
Completed study Official Study Title a SUPar guided doublE-blind Randomized clinical trial of Initiation Of antibiotics foR presumed infection at the emergency department Brief Description SUPERIOR is a randomized clinical trial aiming to evaluate suPAR - guided medical intervention, consisting of early antibiotic administration at the emergency room for presumed infection and sepsis and
Completed study Official Study Title A Personalized Randomized Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis (PROVIDE) Brief Description PROVIDE is a randomized clinical trial aiming to the personalized therapy of patients at septic shock. Using biomarkers, enrolled patients are randomized through a double-dummy approach to immunotherapy or placebo
Completed study Official Study Title A randomized Clinical Trial for enhanced trained Immune responses through bacillus calmette-guérin VAccination to prevenT infections of the Elderly (ACTIVATE) Brief Description ACTIVATE is a randomized clinical trial aiming to investigate if the developing concept of trained immunity i.e. the memory of the innate immune system coming after vaccination
Completed study Official Study Title A double-blind, randomized, placebo-controlled clinical study of the efficacy of INtravenous CLArithromycin as adjunctive treatment in patients with Sepsis and respiratory and multiple organ dysfunction Syndrome Brief Description INCLASS is a randomized clinical trial aiming to compare the efficacy of intravenous clarithromycin over placebo in patients with sepsis and
Completed study Official Study Title INTEgration of clinicaL and Laboratory Information to GENerate technological advanCE for the diagnosis of sepsis Brief Description INTELLIGENCE-1 is a non-interventional trial to validate the diagnostic accuracy of HemoSpec in the diagnosis of sepsis. HemoSpec is a device that integrates information of whole blood cell count, Raman spectra of
Completed study Official Study Title A randomized prospective clinical trial to assess the role of PROcalcitonin-Guided antimicrobial therapy to REduce long-term infectionS Sequelae Brief Description PROGRESS is a randomized clinical trial aiming to test the efficacy of an algorithm of the duration of antimicrobial treatment based on serum procalcitonin in patients with sepsis on
Completed study Official Study Title Prospective Multi-centre Clinical Study to Assess the Clinical Validity of the Heparin Binding Protein Assay to Indicate the Presence and Outcome of Sepsis in Patients With Suspected Infection Following Emergency Department Admission Brief Description PROMPT is a non-interventional trial aiming to validate the diagnostic accuracy of Heparin Binding Protein