Support of publications
Based on its mission, the Hellenic Institute for the Study of Sepsis is supporting three types of publications of manuscripts:
a) manuscripts of the Hellenic Sepsis Study Group;
b) manuscripts on hidradenitis suppurativa; and
c) manuscripts on sepsis.
Support is provided to both pre-clinical and clinical studies and involves the expenses for personnel and consumables.
A list of supported publications is provided below.
The majority of manuscripts published by the Hellenic Sepsis Study Group, are coming from the registry of patients that has started in 2006 and that has been approved by the Ethics Committees of the hospitals (details on Ethical Approval are provided on the Methods section of each manuscript).
The manuscripts are classified by research topic. When the copyright belongs to the authors the entire pdf is given for free or else the manuscript is linked to the PubMed respective site.
Our Library
Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial
Publication in Nature Medicine
A randomized controlled trial of precision bezlotoxumab treatment for Clostridioides difficile infection
Christos Psarrakis, Nikolaos-Renatos Tziolos, Vicky Matzarakis, Vinod Kumar, Emmanouil Stylianakis, Chrysanthi Sidiropoulou, Elisavet Tasouli, Konstantina Iliopoulou, Michael Samarkos, Symeon Metallidis, Sarah Georgiadou, Karolina Akinosoglou, Amalia Bolanou, Erifli Hatziagelaki, Alina Kostaki, Periklis Panagopoulos, Konstantinos Toutouzas, Haralarampos Milionis, Georgios Adamis, Garyfallia Poulakou, Malvina Lada, Athanasios Skoutelis, Zoi Alexiou, Styliani Symbardi, George Chrysos, Mihai G. Netea, Evangelos
Blood biomarker and Raman analysis of leukocytes in the multicenter INTELLIGENCE trials: at the Intensive Care Unit (INTELLIGENCE-1) and the Emergency Department (INTELLIGENCE-2)
Evangelos J. Giamarellos-Bourboulis, Daniel Thomas-Rüddel, Aikaterini Pistiki, Anuradha Ramoji, Oleg Ryabchykov, Kazi Sultana Farhana Azam, Konstantinos Toutouzas, Athanasios Prekates, Stylianos Karatzas, Christos Mathas, Antigone Kotsaki, Stamatios Chalvatzis, Nikolaos Antonakos, Georgia Damoraki, Jan Rüger, Florian Knorr, Natalie Arend, Anja Silge, Iwan Schie, Jesper Eugen-Olsen, Thomas Bocklitz, Michael Bauer, Johannes Winning, Michael Kiehntopf, Jürgen Popp, Frank
Efficacy of anakinra in reducing progression to organ dysfunction in patients with pneumonia (INSPIRE): a randomised, double-blind, placebo-controlled phase IIa trial
Georgios Tavoulareas, Olga Kontakou-Zoniou, Nikolaos Antonakos, Elisavet Tasouli, George Adamis, Nikolaos Kakavoulis, Evangelos Michelakis, Ilias Skopelitis, Konstantina Dakou, Christos Psarrakis, Panagiotis Koufargyris, Myrto Astriti, Styliani Sympardi, and Evangelos J. Giamarellos-Bourboulis The Lancet Regional Health - Europe 2026;62: 101573 DOI: 10.1016/j.lanepe.2025.101573Download pdf 🡇 Funding Hellenic Institute for the Study of Sepsis; PHC Europe BV;
Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial
Evangelos J. Giamarellos-Bourboulis, Antigone Kotsaki, Ioanna Kotsamidi, Aikaterini Efthymiou, Vasiliki Koutsoukou, Johannes Ehler, Alexandra Paridou, Frantzeska Frantzeskaki, Marcella C. A. Müller, Peter Pickkers, Sylvain Meylan, Ioannis Nikolopoulos, Mihaela Lupse, Alexandra Gavala, Glykeria Vlachogianni, Nicky Solomonidi, Antonia Alevizou, Eumorfia Kondili, Eleni Antoniadou, Maria Nakou, Nikolaos Markou, Erifili Hatziagelaki, Athanassios Prekates, Apostolos Komnos, Lieke Bakkerus, Marleen A.
Hydrogen sulfide to modulate Glycated hemoglobin and gut microbiome in type 2 diabetes mellitus
Sokratis Katopodis, Emmanouil Stylianakis, Panagiotis Koufargyris, Maria Mouktaroudi, Konstantina Dakou, Spyros Foutadakis, Georgia Damoraki, Konstantinos Triantafyllou, Evangelos J. Giamarellos-Bourboulis, Erifili Hatziagelaki Metabolism Open, Volume 28, 2025, 100405, ISSN 2589-9368 DOI: 10.1016/j.ebiom.2016.03.006Download pdf 🡇 Funding This study was funded by the Hellenic Institute for the Study of Sepsis (HISS). Keywords: Hydrogen sulfide;
An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis
Pinzauti David, Biazzo Manuele, Podrini Christine, Alevizou Antonia, Safarika Asimina, Damoraki Georgia, Koufargyris Panagiotis, Tasouli Elisavet, Skopelitis Ilias, Poulakou Garyfallia, Sympardi Styliani and Evangelos J. Giamarellos-Bourboulis Front. Cell. Infect. Microbiol. 15:1656171 DOI: 10.3389/fcimb.2025.1656171Download pdf 🡇 Funding The author(s) declare financial support was received for the research and/or publication of this article. The