COVID-19

1 July, 2021

Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19)

2024-04-01T07:28:20+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19|

Maria Saridaki, Simeon Metallidis, Sotiria Grigoropoulou, Emmanouil Vrentzos, Malvina Lada, Katerina Argyraki, Olga Tsachouridou, Anna Georgiadou, Anil Vasishta, Evangelos J. Giamarellos-Bourboulis European Journal of Clinical Microbiology & Infectious Diseases 2021 Jul;40(7):1405-1412 DOI: 10.1007/s10096-020-04145-7Download pdf 🡇 Funding The study was funded in part by the Hellenic Institute for the Study of Sepsis and

23 April, 2021

FERMIN

2023-01-15T21:59:11+03:00By hiss|Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: COVID-19|

Completed study Official Study Title FEnofibRate as a Metabolic INtervention for Coronavirus Disease 2019 (COVID-19): A randomized controlled trial (FERMIN trial) Brief Description FERMIN is a randomized clinical trial aiming to assess the clinical impact of fenofibrate to improve clinical outcomes in patients with COVID-19. Details Status: Completed Study Type: Interventional (Clinical Trial)

8 March, 2021

An open label trial of anakinra to prevent respiratory failure in COVID-19

2024-03-29T14:13:13+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: Anakinra, COVID-19, suPAR|

Evdoxia Kyriazopoulou, Periklis Panagopoulos, Symeon Metallidis, George N Dalekos, Garyphallia Poulakou, Nikolaos Gatselis, Eleni Karakike, Maria Saridaki, Georgia Loli, Aggelos Stefos, Danai Prasianaki, Sarah Georgiadou, Olga Tsachouridou, Vasileios Petrakis, Konstantinos Tsiakos, Maria Kosmidou, Vassiliki Lygoura, Maria Dareioti, Haralampos Milionis, Ilias C Papanikolaou, Karolina Akinosoglou, Dimitra-Melia Myrodia, Areti Gravvani, Aliki Stamou, Theologia Gkavogianni, Konstantina Katrini,

1 February, 2021

Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019

2024-03-29T14:07:31+03:00By hiss|Categories: Publications|Tags: COVID-19, Sepsis|

Timothy E Sweeney, Oliver Liesenfeld, James Wacker, Yudong D He, David Rawling, Melissa Remmel, Sabrina Coyle, Uros Midic, Antigone Kotsaki, Aggeliki Kanavou, Konstantinos Leventogiannis, Ioanna Kontogeorgou, Evangelos J. Giamarellos-Bourboulis Critical Care Medicine 2021 Feb 1;49(2):e170-e178 DOI: 10.1097/CCM.0000000000004786 Download pdf 🡇 Funding Part of the study was funded by the Hellenic Institute

13 January, 2021

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

2023-02-16T13:35:55+03:00By hiss|Categories: Genetics, Publications|Tags: COVID-19, genetics|

Anna C Aschenbrenner, Maria Mouktaroudi, Benjamin Krämer, Marie Oestreich, Nikolaos Antonakos, Melanie Nuesch-Germano, Konstantina Gkizeli, Lorenzo Bonaguro, Nico Reusch, Kevin Baßler, Maria Saridaki, Rainer Knoll, Tal Pecht, Theodore S Kapellos, Sarandia Doulou, Charlotte Kröger, Miriam Herbert, Lisa Holsten, Arik Horne, Ioanna D Gemünd, Nikoletta Rovina, Shobhit Agrawal, Kilian Dahm, Martina van Uelft, Anna Drews,

1 December, 2020

SAVE-MORE

2024-03-14T14:28:56+03:00By hiss|Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: Anakinra, COVID-19|

Completed study Official Study Title suPAR-guided Anakinra treatment for Validation of the risk and Early Management Of seveRE respiratory failure by COVID-19: The SAVE-MORE Double-blind, Randomized, Phase III Confirmatory Trial Brief Description SAVE-MORE is a double-blind randomized clinical trial aiming to study the early treatment of patients with COVID-19 pneumonia with anakinra guided by

19 November, 2020

A novel optical biosensor for the early diagnosis of sepsis and severe Covid-19: the PROUD study

2024-03-29T13:55:21+03:00By hiss|Categories: Biomarkers, Publications|Tags: clinical trial, COVID-19, Sepsis|

Sarantia Doulou, Konstantinos Leventogiannis, Maria Tsilika, Matthew Rodencal, Konstantina Katrini, Nikolaos Antonakos, Miltiades Kyprianou, Emmanouil Karofylakis, Athanassios Karageorgos, Panagiotis Koufargyris, Gennaios Christopoulos, George Kassianidis, Kimon Stamatelopoulos, Robert Newberry, Evangelos J. Giamarellos-Bourboulis BMC Infectious Diseases 2020 Nov 19;20(1):860 DOI: 10.1186/s12879-020-05607-1Download pdf 🡇 Funding The study was funded in part by the Hellenic Institute

1 November, 2020

Soluble Urokinase Receptor (SuPAR) in COVID-19-Related AKI

2023-02-16T13:38:04+03:00By hiss|Categories: Publications|Tags: COVID-19, suPAR|

Tariq U Azam, Husam R Shadid, Pennelope Blakely, Patrick O'Hayer, Hanna Berlin, Michael Pan, Peiyao Zhao, Lili Zhao, Subramaniam Pennathur, Rodica Pop-Busui, Izzet Altintas, Jens Tingleff, Marius A Stauning, Ove Andersen, Maria-Evangelia Adami, Nicky Solomonidi, Maria Tsilika, Pinkus Tober-Lau, Eleni Arnaoutoglou, Verena Keitel, Frank Tacke, Athanasios Chalkias, Sven H Loosen, Evangelos J. Giamarellos-Bourboulis, Jesper

1 November, 2020

Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Coronavirus

2024-03-29T13:45:05+03:00By hiss|Categories: Pathogenesis, Publications|Tags: COVID-19|

Georgios Renieris, Konstantina Katrini, Christina Damoulari, Karolina Akinosoglou, Christos Psarrakis, Magdalini Kyriakopoulou, George Dimopoulos, Malvina Lada, Panagiotis Koufargyris, Evangelos J. Giamarellos-Bourboulis Shock 2020 Nov;54(5):633-637 DOI: 10.1097/SHK.0000000000001562Download pdf 🡇 Funding GR is funded from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement grant European Sepsis Academy (agreement

8 July, 2020

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

2024-03-29T13:31:59+03:00By hiss|Categories: Pathogenesis, Publications|Tags: Anakinra, COVID-19|

George Dimopoulos, Quirijn de Mast, Nikolaos Markou, Maria Theodorakopoulou, Apostolos Komnos, Maria Mouktaroudi, Mihai G Netea, Themistoklis Spyridopoulos, Rebecca J Verheggen, Jacobien Hoogerwerf, Alexandra Lachana, Frank L van de Veerdonk, Evangelos J. Giamarellos-Bourboulis Cell Host & Microbe 2020 Jul 8;28(1):117-123.e1 DOI 10.1016/j.chom.2020.05.007Download pdf 🡇 Funding The study was funded in part by the