COVID-19

25 February, 2022

Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure

2023-02-16T13:21:55+03:00By hiss|Categories: Publications|Tags: COVID-19, Sepsis, suPAR|

Evangelos J. Giamarellos-Bourboulis, Garyfallia Poulakou, Aline de Nooijer, Haralampos Milionis, Simeon Metallidis, Michalis Ploumidis, Pinelopi Grigoropoulou, Aggeliki Rapti, Francesco Vladimiro Segala, Evangelos Balis, Efthymia Giannitsioti, Paola Rodari, Ilias Kainis, Zoi Alexiou, Emanuele Focà, Brollo Lucio, Nikoletta Rovina, Laura Scorzolini, Maria Dafni, Sofia Ioannou, Alessandro Tomelleri, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Christina

1 December, 2021

Early Start of Oral Clarithromycin Is Associated with Better Outcome in COVID-19 of Moderate Severity: The ACHIEVE Open-Label Single-Arm Trial

2023-02-16T13:22:30+03:00By hiss|Categories: Publications|Tags: clarithromycin, clinical trial, COVID-19|

Konstantinos Tsiakos, Antonios Tsakiris, Georgios Tsibris, Pantazis-Michael Voutsinas, Periklis Panagopoulos, Maria Kosmidou, Vasileios Petrakis, Areti Gravvani, Theologia Gkavogianni, Eleftherios Klouras, Konstantina Katrini, Panagiotis Koufargyris, Iro Rapti, Athanassios Karageorgos, Emmanouil Vrentzos, Christina Damoulari, Vagia Zarkada, Chrysanthi Sidiropoulou, Sofia Artemi, Anastasios Ioannidis, Androniki Papapostolou, Evangelos Michelakis, Maria Georgiopoulou, Dimitra-Melia Myrodia, Panteleimon Tsiamalos, Konstantinos Syrigos, George Chrysos,

1 October, 2021

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

2024-04-02T18:13:24+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: Anakinra, clinical trial, COVID-19|

Evdoxia Kyriazopoulou, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Georgios Adamis, Konstantinos Tsiakos, Archontoula Fragkou, Aggeliki Rapti, Christina Damoulari, Massimo Fantoni, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Maria Tsilika, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Evangelos Kostis, Lorenzo Dagna, Panagiotis Koufargyris, Katerina Dimakou, Spyridon Savvanis, Glykeria

1 September, 2021

The Role of Macrolides for the Management of Community-Acquired Pneumonia and Pneumonia by the Novel Coronavirus SARS-CoV-2 (COVID-19): A Position Paper by Four Medical Societies from Greece

2024-04-02T18:01:32+03:00By hiss|Categories: Publications, Therapeutics|Tags: clarithromycin, COVID-19, pneumonia|

Evangelos J. Giamarellos-Bourboulis, George L Daikos, Panagiotis Gargalianos, Charalambos Gogos, Marios Lazanas, Periklis Panagopoulos, Garyphallia Poulakou, Helen Sambatakou, Michael Samarkos Infectious Diseases and Therapy 2021 Sep;10(3):1081-1095 DOI: 10.1007/s40121-021-00471-1Download pdf 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis. No Rapid Service Fee was received by the

1 July, 2021

Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19)

2024-04-01T07:28:20+03:00By hiss|Categories: Biomarkers, Publications|Tags: COVID-19|

Maria Saridaki, Simeon Metallidis, Sotiria Grigoropoulou, Emmanouil Vrentzos, Malvina Lada, Katerina Argyraki, Olga Tsachouridou, Anna Georgiadou, Anil Vasishta, Evangelos J. Giamarellos-Bourboulis European Journal of Clinical Microbiology & Infectious Diseases 2021 Jul;40(7):1405-1412 DOI: 10.1007/s10096-020-04145-7Download pdf 🡇 Funding The study was funded in part by the Hellenic Institute for the Study of Sepsis and

23 April, 2021

FERMIN

2023-01-15T21:59:11+03:00By hiss|Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: COVID-19|

Completed study Official Study Title FEnofibRate as a Metabolic INtervention for Coronavirus Disease 2019 (COVID-19): A randomized controlled trial (FERMIN trial) Brief Description FERMIN is a randomized clinical trial aiming to assess the clinical impact of fenofibrate to improve clinical outcomes in patients with COVID-19. Details Status: Completed Study Type: Interventional (Clinical Trial)

8 March, 2021

An open label trial of anakinra to prevent respiratory failure in COVID-19

2024-03-29T14:13:13+03:00By hiss|Categories: Multicenter studies in Greece, Publications, Therapeutics|Tags: Anakinra, COVID-19, suPAR|

Evdoxia Kyriazopoulou, Periklis Panagopoulos, Symeon Metallidis, George N Dalekos, Garyphallia Poulakou, Nikolaos Gatselis, Eleni Karakike, Maria Saridaki, Georgia Loli, Aggelos Stefos, Danai Prasianaki, Sarah Georgiadou, Olga Tsachouridou, Vasileios Petrakis, Konstantinos Tsiakos, Maria Kosmidou, Vassiliki Lygoura, Maria Dareioti, Haralampos Milionis, Ilias C Papanikolaou, Karolina Akinosoglou, Dimitra-Melia Myrodia, Areti Gravvani, Aliki Stamou, Theologia Gkavogianni, Konstantina Katrini,

1 February, 2021

Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019

2024-03-29T14:07:31+03:00By hiss|Categories: Publications|Tags: COVID-19, Sepsis|

Timothy E Sweeney, Oliver Liesenfeld, James Wacker, Yudong D He, David Rawling, Melissa Remmel, Sabrina Coyle, Uros Midic, Antigone Kotsaki, Aggeliki Kanavou, Konstantinos Leventogiannis, Ioanna Kontogeorgou, Evangelos J. Giamarellos-Bourboulis Critical Care Medicine 2021 Feb 1;49(2):e170-e178 DOI: 10.1097/CCM.0000000000004786 Download pdf 🡇 Funding Part of the study was funded by the Hellenic Institute

13 January, 2021

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

2023-02-16T13:35:55+03:00By hiss|Categories: Genetics, Publications|Tags: COVID-19, genetics|

Anna C Aschenbrenner, Maria Mouktaroudi, Benjamin Krämer, Marie Oestreich, Nikolaos Antonakos, Melanie Nuesch-Germano, Konstantina Gkizeli, Lorenzo Bonaguro, Nico Reusch, Kevin Baßler, Maria Saridaki, Rainer Knoll, Tal Pecht, Theodore S Kapellos, Sarandia Doulou, Charlotte Kröger, Miriam Herbert, Lisa Holsten, Arik Horne, Ioanna D Gemünd, Nikoletta Rovina, Shobhit Agrawal, Kilian Dahm, Martina van Uelft, Anna Drews,

1 December, 2020

SAVE-MORE

2024-03-14T14:28:56+03:00By hiss|Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: Anakinra, COVID-19|

Completed study Official Study Title suPAR-guided Anakinra treatment for Validation of the risk and Early Management Of seveRE respiratory failure by COVID-19: The SAVE-MORE Double-blind, Randomized, Phase III Confirmatory Trial Brief Description SAVE-MORE is a double-blind randomized clinical trial aiming to study the early treatment of patients with COVID-19 pneumonia with anakinra guided by