1 June, 2019

Association of the early absolute CD64-expressing neutrophil count and sepsis outcome

2023-02-16T14:34:38+03:00By |Categories: Biomarkers, Other Grants, Publications|Tags: , , |

Aggeliki Xini, Aikaterini Pistiki, Malvina Lada, Evangelos J. Giamarellos-Bourboulis, Georgios Dimopoulos European Journal of Clinical Microbiology & Infectious Diseases 2019 Jun;38(6):1123-1128 DOI: 10.1007/s10096-019-03507-0View article 🡇 FundingThe study was funded by the Hellenic Institute for the Study of Sepsis. The funders did not have any role in the study design, analysis, and interpretation of data

31 January, 2019

Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis.

2023-02-16T14:36:48+03:00By |Categories: Publications|Tags: |

Eleni Karakike , Evangelos J. Giamarellos-Bourboulis Frontiers in Immunology 2019 Jan 31;10:55 DOI 10.3389/fimmu.2019.00055 View article 🡇 Funding EK is funded by the Horizon 2020 Marie Skłodowska-Curie Grant European Sepsis Academy (grant 676129 paid to the University of Athens). EG-B has received funding from the FrameWork 7 program HemoSpec and

17 October, 2018

MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis

2024-03-28T18:19:40+03:00By |Categories: Biomarkers, Publications|Tags: , |

Patrick Möhnle, Simon Hirschberger, Ludwig Christian Giuseppe Hinske, Josef Briegel, Max Hübner, Sebastien Weis, Georgios Dimopoulos, Michael Bauer, Evangelos J. Giamarellos-Bourboulis, Simone Kreth Molecular Medicine 2018 Oct 17;24(1):54 DOI: 10.1186/s10020-018-0056-zDownload pdf 🡇 Funding This work has been funded by the Charles-Evans-Foundation, New Jersey, USA. Sebastian Weis and Michael Bauer are supported by the

1 October, 2018

SUPERIOR

2024-02-07T15:50:04+03:00By |Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: |

Completed study Official Study Title a SUPar guided doublE-blind Randomized clinical trial of Initiation Of antibiotics foR presumed infection at the emergency department Brief Description SUPERIOR is a randomized clinical trial aiming to evaluate suPAR - guided medical intervention, consisting of early antibiotic administration at the emergency room for presumed infection and sepsis and

1 October, 2018

How well does qSOFA correspond to underlying systemic inflammatory response?

2023-02-16T14:38:02+03:00By |Categories: Biomarkers, Publications|Tags: , |

Karolina Akinosoglou, Spyridoula Theodoraki, Theologia Gkavogianni, Aikaterini Pistiki, Evangelos J. Giamarellos-Bourboulis, Charalambos A Gogos Cytokine 2018 Oct;110:288-290 DOI: 10.1016/j.cyto.2018.01.019View article 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: Anti-inflammatory mediators; Pro-inflammatory mediators; SIRS; Sepsis; qSOFA

1 June, 2018

Reduced circulating B cells and plasma IgM levels are associated with decreased survival in sepsis – A meta-analysis

2023-02-16T14:38:40+03:00By |Categories: Biomarkers, Publications|Tags: , |

Christian Krautz, Sarah L Maier, Maximilian Brunner, Melanie Langheinrich, Evangelos J. Giamarellos-Bourboulis, Charalambos Gogos, Apostolos Armaganidis, Frank Kunath, Robert Grützmann, Georg F Weber Journal of Critical Care 2018 Jun;45:71-75 DOI: 10.1016/j.jcrc.2018.01.013 View article 🡇 Keywords: Circulating B cells; Plasma IgM; Sepsis; Sepsis outcome

29 May, 2018

Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection

2024-03-28T17:18:57+03:00By |Categories: Pathogenesis, Publications|Tags: |

Dimitrios Sinapidis, Vassileios Kosmas, Vasileios Vittoros, Ioannis M. Koutelidakis, Aikaterini Pantazi, Aggelos Stefos, Konstantinos E. Katsaros, Karolina Akinosoglou, Magdalini Bristianou, Konstantinos Toutouzas, Michael Chrisofos and Evangelos J. Giamarellos-Bourboulis BMC Infectious Diseases, May 2018 DOI 10.1186/s12879-018-3156-zDownload pdf 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis.

3 March, 2018

Increases in inflammatory and CD14dim/CD16pos/CD45pos patrolling monocytes in sepsis: correlation with final outcome

2023-02-16T14:39:51+03:00By |Categories: Other Grants, Publications|Tags: |

Gabriela Gainaru, Antonios Papadopoulos, Iraklis Tsangaris, Malvina Lada, Evangelos J. Giamarellos-Bourboulis, Aikaterini Pistiki Critical Care 2018 Mar 3;22(1):56 DOI: 10.1186/s13054-018-1977-1View article 🡇 Funding The study was funded by the Hellenic Institute for the Study of Sepsis. Keywords: Gram-negative; Inflammatory monocytes; Patrolling monocytes; Sepsis; Survival

1 February, 2018

Haplotypes composed of minor frequency single nucleotide polymorphisms of the TNF gene protect from progression into sepsis: A study using the new sepsis classification

2024-03-28T17:04:25+03:00By |Categories: Genetics, Publications|Tags: , |

Theodoros Retsas, Klaus Huse, Lazaros-Dimitrios Lazaridis, Niki Karampela, Michael Bauer, Matthias Platzer, Virginia Kolonia, Eirini Papageorgiou, Evangelos J. Giamarellos-Bourboulis, George Dimopoulos International Journal of Infectious Diseases 2018 Feb;67:102-106 DOI: 10.1016/j.ijid.2017.12.008Download pdf 🡇 FundingThe study was funded in part by the Hellenic Institute for the Study of Sepsis and by the Federal Ministry of

1 December, 2017

PROVIDE

2024-10-18T11:36:45+03:00By |Categories: Completed, Interventional, Sepsis and severe infections, Studies|Tags: , |

Completed study Official Study Title A Personalized Randomized Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis (PROVIDE) Brief Description PROVIDE is a randomized clinical trial aiming to the personalized therapy of patients at septic shock. Using biomarkers, enrolled patients are randomized through a double-dummy approach to immunotherapy or placebo

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